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Table 1 The significantly enriched GO_BP terms (top 1) and KEGG pathways of up-regulated DEGs

From: Potential molecular characteristics in situ in response to repetitive UVB irradiation

Term Count Gene lists P-Value Adjusted P-value
GO_BP: enrichment Score: 3.4367879252049858
 GO_BP: 0048066 pigmentation during development 7 DCT, SOX10, TYRP1, TYR, MLPH, KIT, GPR143 3.63E-08 5.65E-05
 GO_BP: 0043473 pigmentation 7 DCT, SOX10, TYRP1, TYR, MLPH, KIT, GPR143 5.78E-06 0.009009
 GO_BP: 0042438 melanin biosynthetic process 3 DCT, TYRP1, TYR 1.59E-03 2.449285
 GO_BP: 0006582 melanin metabolic process 3 DCT, TYRP1, TYR 2.03E-03 3.123208
 GO_BP: 0046148 pigment biosynthetic process 4 DCT, TYRP1, TYR, GPR143 3.30E-03 5.019067
 GO_BP: 0042440 pigment metabolic process 4 DCT, TYRP1, TYR, GPR143 4.96E-03 7.448208
 GO_BP: 0030318 melanocyte differentiation 3 SOX10, TYRP1, MLPH 5.02E-03 7.534839
 GO_BP: 0050931 pigment cell differentiation 3 SOX10, TYRP1, MLPH 5.76E-03 8.604376
KEGG
 hsa04080: Neuroactive ligand-receptor interaction 6 SSTR4, GPR156, KISS1R, OPRL1, NPBWR1, GRIN1 1.58E-02 13.80265
 hsa04916: Melanogenesis 4 DCT, TYRP1, TYR, KIT 1.99E-02 17.11413
 hsa00350: Tyrosine metabolism 3 DCT, TYRP1, TYR 2.73E-02 22.81886
  1. Note: GO gene ontology, BP biological process, KEGG Kyoto encyclopedia of genes and genomes, DEGs differentially expressed genes. Count, the number of DEGs enriched in the corresponding term. The gene symbols were listed in accordance with the Gene database at NCBI (National Center for Biotechnology Information, http://www.ncbi.nlm.nih.gov/gene/?term)