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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Metachronous serous endometrial intraepithelial carcinoma and serous peritoneal carcinoma: analysis of probable independent lesions

Fig. 1

Macroscopic and microscopic features of serous endometrial intraepithelial carcinoma (SEIC) and peritoneal carcinoma. a The resected uterus had several leiomyomas occupying the uterine cavity (left). The cut surface of the vertical axis is shown (right). The surface in the dotted rectangle indicates the SEIC lesion. b The peritoneal carcinoma developed as a cyst on the surface of intestinal mesenchyme (left). Inside of the cyst, a papillary lesion was detected (right). c Hematoxylin-eosin (HE) staining of the SEIC in atrophic endometrium. Hyalinized submucosal leiomyoma is observed in the adjacent tissue. d HE staining of the peritoneal carcinoma. Proliferating papillary tumor cells with atypia are observed. e, f Immunostaining for p53 in the SEIC (E) and the peritoneal carcinoma (F). Both lesions show diffusely positive staining. g, h Immunostaining for WT-1 in the SEIC (G) and the peritoneal carcinoma (H). The SEIC is negative for WT-1 (G), whereas the peritoneal carcinoma shows focal positive staining (H). Serial staining sections are shown

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