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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report

Fig. 3

a FISH assay with a break apart probe for the ALK gene shows one intact yellow signal and one separated red and green signal per nucleus in tumor cells, indicating the presence of a rearrangement in the ALK gene. b The 5′ RACE analysis identified ATIC as a fusion partner. The sequence of the second round PCR product covering the fusion point (arrow) is shown. c The results of the RT-PCR analysis for ATIC-ALK are shown. PT: Present tumor, UT: Unrelated tumor (lung tumor), DW: Distilled Water, GAPDH: glyceraldehydes-3-phosphate dehydrogenase

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Diagnostic Pathology

ISSN: 1746-1596

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