Double-hit lymphomas: clinical, morphological, immunohistochemical and cytogenetic study in a series of Brazilian patients with high-grade non-Hodgkin lymphoma

Table 4 Immunohistochemistry (IHC) for Myc, Bcl2 and Bcl6 and cytogenetic (FISH) for MYC, BCL2 and BCL6, considering the group of DLBCL: sensitivity (S), specificity (E), positive predictive value (PPV) and negative predictive value (NPV), accuracy (A) and Kappa coefficient, with respective ranges of 95% confidence

	n	FISH+	p*	S	E	PPV	NPV	A	Kappa
MYC (n = 70)
IHC negative	59	1 (1.7%)	0.062	0.67	0.87	0.18	0.98	0.86 [0.78;0.94]	0.23 [0.0;0.67]
IHC positive	11	2 (18.1%)	0.062	0.67	0.87	0.18	0.98	0.86 [0.78;0.94]	0.23 [0.0;0.67]
BCL2 (n = 71)
IHC negative	42	2 (4.7%)	0.005	0.81	0.66	0.31	0.95	0.69 [0.58;0.79]	0.29 [0.04;0.54]
IHC positive	29	9 (31%)	0.005	0.81	0.66	0.31	0.95	0.69 [0.58;0.79]	0.29 [0.04;0.54]
BCL6 (n = 70)
IHC negative	48	6 (12.5%)	1.000	0.33	0.69	0.13	0.87	0.64 [0.53;0.76]	0.01 [0.0;0.32]
IHC positive	22	3 (13.6%)	1.000	0.33	0.69	0.13	0.87	0.64 [0.53;0.76]	0.01 [0.0;0.32]

ISSN: 1746-1596