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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Epithelioid schwannoma of the skin displaying unique histopathological features: a teaching case giving rise to diagnostic difficulties on a morphological examination of a resected specimen, with a brief literature review

Fig. 2

The gross and microscopic findings of the resected specimen of epithelioid schwannoma arising from the superficial subcutaneous soft tissue. a Tumor extirpation was performed, and a gross examination of the cut surface revealed an encapsulated, well-demarcated nodular lesion, yellow-whitish in color, partly filled with blood, measuring 5 × 4 mm in diameter. Bar = 4 mm. b On scanning magnification (H&E stain), this superficial subcutaneous tumor was found to contain a peripheral cyst-like, degenerative cavity filled with red blood cells and showed an encapsulated and well-circumscribed nodule surrounded by dense, hyalinized and layered fibrocollagenous stroma (arrows), reminiscent of a vascular-like structure. Bar = 2 mm. c Under a low-power view, this tumor predominantly comprised a solid proliferation of characteristic epithelioid cells, embedded partially in a small amount of hyalinized and/or myxoid stroma. Scattered small blood vessels intervened in this epithelioid schwannoma. Neither an infiltrative appearance nor necrotic foci were evident. Bar = 100 μm (H&E stain) (original magnification: × 100). d Under a high-power view, these neoplastic cells revealed mildly atypical epithelioid cells with mildly enlarged, pleomorphic and round to partially spindled, polygonal nuclei and abundant vacuolated or clear cytoplasm with very few mitotic figures (much less than 1/50 high-power fields), less than three nuclear size variations, and frequent intranuclear pseudo-inclusions. Bar = 25 μm (H&E stain) (original magnification: × 400)

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