Table 3 Immunohistological features of epithelioid schwannoma and the other tumors of its differential diagnoses
S-100 protein | Vimentin | CKs | EMA | α-SMA | Desmin | CD10 | CD31 | CD34 | CD68 | p63 | Type IV collagen | Melan-A | HMB-45 | CDK4 | MDM2 | p53 | Ki67 (MIB-1) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epithelioid schwannoma | + | + | - | - | - | - | - | - | - | - | - | + | - | - | - | - | - | Very low |
Epithelioid MPNST | + | + | - | - | - | - | - | - | - | - | - | + | - | - | - | - | + | High |
Soft tissue myoepithelioma | + | + | + | + | F+ | F+ | F+ | - | - | - | F+ | + | - | - | - | - | - | Very low |
Epithelioid hemangioendothelioma | - | + | F+ | - | - | - | F+ | + | + | - | - | + | - | - | - | - | NG | Low to intermediate |
Perineurioma of sclerosing or reticular variants | - | + | - | + | - | - | + | - | - | - | - | + | - | - | - | - | - | Very low |
Epithelioid leiomyoma | - | + | - | - | + | + | + | - | - | - | + | - | - | - | - | - | - | Very low |
Malignant melanoma | + | + | - | - | - | - | + | - | - | - | - | - | + | + | - | - | + | Very high |
Liposarcoma, dedifferentiated | - | + | - | - | - | - | - | - | - | - | - | - | - | - | + | + | + | HIgh |