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Table 1 DNA Sequencing and IHC Results

From: TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer

Sample TP53 Mutation by Sequencing Class of Mutation IHC Results Proportion of Tumor cells (%)
1
2
3
4
5
R306 (abundance: 61.5%)
P190 (abundance: 5.7%)
Negative
Exon 8 C > T (abundance: 33.8%)
R282W (abundance: 88.4%)
II
III
Wild-type
I
II
++
+
±
-
+++
80
90
75
85
80
  1. IHC immunohistochemistry
  2. P53 nuclei staining: -, complete absence of staining; ±, <10% of tumor cells with faint staining intensity; +, 10%-50% of tumor cells with faint staining intensity; ++, ≥50% of tumor cells with moderate staining intensity; +++, ≥50% of tumor cells with strong staining intensity