TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer

Table 1 DNA Sequencing and IHC Results

Sample	TP53 Mutation by Sequencing	Class of Mutation	IHC Results	Proportion of Tumor cells (%)
1 2 3 4 5	R306 (abundance: 61.5%) P190 (abundance: 5.7%) Negative Exon 8 C > T (abundance: 33.8%) R282W (abundance: 88.4%)	II III Wild-type I II	++ + ± - +++	80 90 75 85 80

IHC immunohistochemistry
P53 nuclei staining: -, complete absence of staining; ±, <10% of tumor cells with faint staining intensity; +, 10%-50% of tumor cells with faint staining intensity; ++, ≥50% of tumor cells with moderate staining intensity; +++, ≥50% of tumor cells with strong staining intensity

ISSN: 1746-1596