Ki-67 as a controversial predictive and prognostic marker in breast cancer patients treated with neoadjuvant chemotherapy

Table 2 Association between age, hormone receptor positivity and therapy response

Therapy response category	N	HR status (%)		p¹	Average age at diagnosis (year ± SD)			p²
Therapy response category	N	HR+	HR−	p¹	HR+	HR−	all	p²
pCR	23	5 (21.7)	18 (78.3)	<0.001	44.2 ± 12.6	46.4 ± 13.8	46.0 ± 13.3	0.008
pPR	73	55 (75.3)	18 (24.7)		50.0 ± 11.0	52.3 ± 12.8	50.4 ± 11.4
pNR	24	20 (83.3)	4 (16.7)		55.9 ± 10.7	53.3 ± 14.5	55.6 ± 11.0

HR – hormone receptor positive (+) or negative (−)
¹two-sided Fisher’s exact test; ²Kruskal-Wallis H-test with Dunn’s posthoc (multiple comparison) test for all samples without regarding the HR status

ISSN: 1746-1596