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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Immunohistochemistry of sarcolemmal membrane-associated proteins in formalin-fixed and paraffin-embedded skeletal muscle tissue: a promising tool for the diagnostic evaluation of common muscular dystrophies

Fig. 2

Comparison of IHC results between frozen sections (left column) and FFPE sections (right column) in patient 12, with not-specified muscular dystrophy. Equivalent sarcolemmal staining for spectrin (a, b), the rod domain of dystrophin (c, d), the C-terminus of dystrophin (e, f), β-dystroglycan (i, j), α-sarcoglycan (k, l), β-sarcoglycan (m, n), γ-sarcoglycan (o, p), and dysferlin (q, r) was evident. The N-terminus of dystrophin could not be stained in the FFPE section (h) while its expression was apparent in the frozen section (g). Original magnification, ×400

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Diagnostic Pathology

ISSN: 1746-1596

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