Fig. 4From: Immunohistochemistry of sarcolemmal membrane-associated proteins in formalin-fixed and paraffin-embedded skeletal muscle tissue: a promising tool for the diagnostic evaluation of common muscular dystrophiesComparison of FFPE sections of control muscle (left column) and muscle biopsy from patients (right column). Dysferlin was absent from the FFPE section of patient 3 (b), and apparent in control tissue (a). The FFPE sections of patient 8 showed no expression of the rod domain (d) and C-terminus (f) of dystrophin, while control tissue showed positive staining of the rod domain (c) and C-terminus (e) of dystrophin. Based on the whole clinical picture, histology, and the IHC study of FFPE sections, a diagnosis of dysferlinopathy and DMD were established for patients 3 and 8, respectively. Original magnification, ×400Back to article page