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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Immunohistochemistry of sarcolemmal membrane-associated proteins in formalin-fixed and paraffin-embedded skeletal muscle tissue: a promising tool for the diagnostic evaluation of common muscular dystrophies

Fig. 4

Comparison of FFPE sections of control muscle (left column) and muscle biopsy from patients (right column). Dysferlin was absent from the FFPE section of patient 3 (b), and apparent in control tissue (a). The FFPE sections of patient 8 showed no expression of the rod domain (d) and C-terminus (f) of dystrophin, while control tissue showed positive staining of the rod domain (c) and C-terminus (e) of dystrophin. Based on the whole clinical picture, histology, and the IHC study of FFPE sections, a diagnosis of dysferlinopathy and DMD were established for patients 3 and 8, respectively. Original magnification, ×400

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