Fig. 1From: Molecular genetics of microsatellite-unstable colorectal cancer for pathologistsAlgorithm for screening newly diagnosed colorectal carcinoma (CRC) for Lynch syndrome (LS). The initial step is to screen cases using immunohistochemistry (IHC) for mismatch repair proteins. When MLH1 and PMS2 are absent, the subsequent step is to utilize BRAF analysis by polymerase chain reaction (PCR) or immunohistochemistryBack to article page