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Table 2 Comparison of the Amsterdam criteria, Amsterdam II criteria, and the revised Bethesda criteria

From: Molecular genetics of microsatellite-unstable colorectal cancer for pathologists

Amsterdam criteria
(meet all sub criteria)
Amsterdam II criteria
(meet all sub criteria)
Revised Bethesda criteria
(meet one of the following sub criteria)
3 or more relatives with histologically confirmed colorectal cancer 3 or more relatives with Lynch syndrome-associated cancer (colorectal cancer or cancer of the endometrium, small intestine, ureter or renal pelvis); cancers are histologically verified Colorectal cancer diagnosed in a patient aged <50 years
2 or more successive generations involved 2 or more successive generations affected Presence of synchronous, metachronous colorectal cancer or other Lynch syndrome-related tumors: cancer of the colorectum, stomach, small intestine, pancreas, biliary tract, renal pelvis, ureter, ovary, brain; sebaceous gland adenoma or carcinoma and keratoacanthoma, regardless of age
1 or more of the cancers diagnosed before age 50 years 1 or more relatives diagnosed before the age of 50 years Colorectal cancer with MSI phenotype, especially lymphocyte infiltration, diagnosed in a patient aged <60 years
One should be a first-degree relative of the other two One should be a first-degree relative of the other two Patient with colorectal cancer and a first-degree relative with a Lynch syndrome-related tumor, with one of these cancers diagnosed at age <50 years
Familial adenomatous polyposis should be excluded Familial adenomatous polyposis should be excluded in cases of colorectal carcinoma Patient with colorectal cancer with two or more first-degree or second-degree relatives with a Lynch syndrome-related tumor, regardless of age