Skip to main content

Table 1 Characteristics of autopsy cases

From: Implication of overexpression of dishevelled-associated activator of morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary Arterial Hypertension (IPAH)

A. PAH Cases
Patient Diagnosis H-E Grade Age (years) Sex Underlying conditions
1a APAH II 4 months Female DORV and VSD
2a APAH II 5 months Female Trisomy 18 and VSD
3a APAH II 6 months Female DORV and VSD
4a APAH II 7 months Female Trisomy 21, ASD, and VSD
5 IPAH III 13 Female  
6 IPAH IV 16 Female  
7a IPAH IV 17 Female  
8a IPAH IV 19 Female  
9a IPAH III 21 Female  
10 IPAH IV 24 Male  
11 APAH VI 29 Male Collagen disease
12 IPAH IV 39 Female  
13 APAH IV 41 Male Malignant lymphoma
14a IPAH III 44 Female  
15a IPAH IV 51 Female  
16a APAH III 63 Male Collagen disease
B. Age-matched controls
Patient Age (years) Sex Underlying conditions   
17 3 Female Pneumonia   
18a 4 Male Leukemia   
19a 11 Female Biliary atresia   
20 14 Female Leukemia   
21a 14 Male Leukemia   
22a 15 Male Leukemia   
23a 16 Male Hypertrophic cardiomyopathy   
24 17 Male Idiopathic myocarditis   
25a 18 Male Ewing sarcoma   
26a 22 Female Suicide   
27a 23 Female Cerebral hemorrhage   
28a 29 Male Chronic hepatitis   
29 42 Male Anterior mediastinal tumor   
30 43 Female Breast cancer   
31a 47 Female Gastric cancer   
32a 56 Female Subacute hepatitis   
C. Summary
  No. Median age Males:females   
PAH cases 16 20 y (4 m - 63 y) 4:12   
IPAH 9 21 y (13 y - 51 y) 1:8   
APAH 7 7 m (4 m - 63 y) 3:4   
Age-matched controls 16 18 y (3 y - 56 y) 8:8   
  1. Cases are in ascending order of age
  2. H-E Grade, Heath–Edwards grade 36; DORV, double outlet right ventricle; VSD, ventricular septal defect; ASD, atrial septal defect
  3. a indicates that positive reactivity against both anti–Dvl-2 antibody and anti–Daam-1 antibody was confirmed in built-in control before further evaluation