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Table 2 Comparison of Lauren subtypes, tumor location, average size and tumor tissue proportion of tumor fragments based on biopsy number and tumor fragment number

From: Tumor containing fragment number influences immunohistochemistry positive rate of HER2 in biopsy specimens of gastric cancer

 

Lauren subtypes, n (%)

P value

Tumor location, n (%)

P value

Average size (mean ± SD, cm)

P value

Tumor tissue proportion (%)

P value

Intestinal

Diffuse

Mixed

Indeterminate

Upper third

Middle third

Lower third

Others

Number of biopsy specimens

    

0.112

    

0.445

 

0.977

 

0.204

1

6 (85.7)

1 (14.3)

0 (0.0)

0 (0.0)

 

2 (28.6)

1 (14.3)

4 (57.1)

0 (0.0)

 

0.194 ± 0.012

 

54.4 ± 10.9

 

2

11 (55.0)

6 (30.0)

1 (5.0)

2 (10.0)

 

5 (25.0)

6 (30.0)

9 (45.0)

0 (0.0)

 

0.201 ± 0.056

 

56.7 ± 16.1

 

3

12 (44.4)

8 (29.6)

7 (25.9)

0 (0.0)

 

10 (37.0)

5 (18.5)

11 (40.7)

1 (3.7)

 

0.192 ± 0.046

 

52.4 ± 15.6

 

4

107 (51.2)

56 (26.8)

43 (20.6)

3 (1.4)

 

58 (27.8)

53 (25.4)

97 (46.4)

1 (0.5)

 

0.199 ± 0.038

 

51.0 ± 17.1

 

5

68 (53.5)

33 (26.0)

26 (20.5)

0 (0.0)

 

39 (30.7)

37 (29.1)

51 (40.2)

0 (0.0)

 

0.195 ± 0.035

 

51.8 ± 17.9

 

6

215 (49.7)

131 (30.3)

84 (19.4)

3 (0.7)

 

87 (20.1)

137 (31.6)

205 (47.3)

4 (0.9)

 

0.196 ± 0.041

 

53.4 ± 18,1

 

7

12 (41.4)

9 (31.0)

7 (24.1)

1 (3.4)

 

6 (20.7)

7 (24.1)

16 (55.2)

0 (0.0)

 

0.193 ± 0.043

 

52.6 ± 18.9

 

8

15 (45.5)

10 (30.3)

8 (24.2)

0 (0.0)

 

6 (18.2)

14 (42.4)

13 (39.4)

0 (0.0)

 

0.200 ± 0.039

 

48.5 ± 19.3

 

10

2 (40.0)

3 (60.0)

0 (0.0)

0 (0.0)

 

0 (0.0)

2 (40.4)

3 (60.0)

0 (0.0)

 

0.202 ± 0.040

 

43.0 ± 15.7

 

Number of tumor fragments

    

0.126

    

0.745

 

0.189

 

0.530

1

31 (60.8)

14 (27.5)

5 (9.8)

1 (2.0)

 

10 (19.6)

11 (21.6)

30 (58.8)

0 (0.0)

 

0.209 ± 0.042

 

48.8 ± 20.4

 

2

46 (54.1)

25 (29.4)

11 (12.9)

3 (3.5)

 

15 (17.6)

29 (34.1)

41 (48.2)

0 (0.0)

 

0.190 ± 0.032

 

50.5 ± 18.9

 

3

91 (53.2)

50 (29.2)

29 (17.0)

1 (0.6)

 

42 (24.6)

49 (28.7)

79 (46.2)

1 (0.6)

 

0.195 ± 0.039

 

50.2 ± 17.3

 

4

184 (52.9)

89 (25.6)

73 (21.0)

2 (0.6)

 

92 (26.4)

105 (30.2)

148 (42.5)

3 (0.9)

 

0.197 ± 0.037

 

53.8 ± 17.0

 

5

48 (41.0)

39 (33.6)

29 (23.9)

1 (0.9)

 

26 (22.2)

37 (31.6)

54 (46.2)

0 (0.0)

 

0.193 ± 0.040

 

52.2 ± 18.0

 

6

47 (41.6)

38 (33.6)

27 (23.9)

1 (0.9)

 

28 (24.8)

29 (25.7)

54 (47.8)

2 (1.8)

 

0.199 ± 0.041

 

54.7 ± 17.7

 

8

1 (25.0)

1 (25.0)

2 (50.0)

0 (0.0)

 

0 (0.0)

1 (25.0)

3 (75.0)

0 (0.0)

 

0.214 ± 0.026

 

52.5 ± 19.3

 

10

0 (0.0)

1 (100.0)

0 (0.0)

0 (0.0)

 

0 (0.0)

1 (100.0)

0 (0.0)

0 (0.0)

 

0.204

 

51.3

 
  1. “n” refers to the number of cases. “Average size” refers to average size of tumor-containing fragments. “Tumor tissue proportion” refers to tumor tissue proportion of tumor-containing fragments