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Table 1 Previously reported cases of malignant gastrointestinal neuroectodermal tumor

From: Malignant gastrointestinal neuroectodermal tumor: a case report and review of the literature

  Report Age (years)/ Sex Location Morphology S100 HMB-45 and Melan A EM Genetic finding Outcome Additional findings
1 Zambrano et al. [2] 15/F Small intestine Oval, spindled + - No melanosomes t(12;22) (q13;q12) DOD at 16 months OLGC
2 21/F Small intestine Oval, spindled + - ND ND DOD at 12 months OLGC
3 35/F Small intestine Oval, spindled + - No melanosomes ND LN and liver metastasis at 12 months OLGC
4 37/F Small intestine Oval, spindled + -   ND NA OLGC
5 13/M Stomach Oval, spindled + - No melanosomes ND recurrences at 12 months OLGC
6 32/M Small intestine Oval, spindled + - ND ND LN mets OLGC
7 Stockman et al. [1]a 30/F Jejunum Epithelioid + - Dense-core granules EWSR1-ATF1 AWD at 21 months  
8 35/M Jejunum Epithelioid + - Dense-core granules EWSR1-ATF1 DOD at 18 months  
9 33/M Ileum Epithelioid + - Dense-core granules EWSR1-CREB1 AWD at 1.5 months  
10 50/F Stomach Epithelioid + - Dense-core granules EWSR1-ATF1 AWD at 24 months  
11 20/F Small intestine Spindled + - Dense-core granules EWSR1 NED at 20 months  
12 52/M Ileum Epithelioid + - ND - DOD at 22 months  
13 46/M Stomach Epithelioid + - ND EWSR1 NA  
14 34/F Stomach Epithelioid, Spindled + - ND EWSR1-ATF1 DOD at 19 months  
15 37/F Ileum Epithelioid + ND ND ND NA  
16 77/F Colon Epithelioid, Spindled + - ND EWSR1-ATF1 DOD at 106 months  
17 31/M Colon Epithelioid + - ND - DOD at 3 months  
18 17/M Small intestine Epithelioid + - ND EWSR1 NA  
19 60/M Iluem Epithelioid + - ND EWSR1-ATF1 AWD at 36 months  
20 60/F Jejunum Epithelioid, Spindled + - ND EWSR1-CREB1 NED at 41 months  
21 56/M Stomach Epithelioid + - ND EWSR1-CREB1 NA  
22 28/F Small intestine Epithelioid + - ND EWSR1 DOD at 23 months  
23 Insabato et al. [6] 29/M Stomach Epithelioid, spindled + - No melanosomes EWSR1 AWD at 74 months Hx of Ewing sarcoma, FLI-1+
24 Zhao et al. [7] 33/F Ileum Epithelioid + -   EWSR1 NA  
25 Kong et al. [5] 17/M Stomach Spindled, round + - ND EWSR1 NED at 10 months OLGC
26 Huang et al. [3] 40/M Stomach Spindled, oval + - ND ND LN mets at diagnosis OLGC
27 Thway et al. [8] 33/M Small intestine Epithelioid, spindled + - ND EWSR1-CREB1 DOD at 7 months Hx of hepato-blastoma
28 Friedrichs et al. [4] 41/M Small intestine Epithelioid + - ND t(12;22) (q13;q12) Liver mets at 6 months OLGC
29 Boland et al. [9] 46/F Stomach Epithelioid + - ND EWSR1-ATF1 NA Oncocytic change
  1. AWD alive with disease, DOD dead of disease, EM electron microscopy, Hx history, mets, metastasis, NA not available, NED no evidence of disease, ND not done, OLGC osteoclast-like giant cells
  2. aEight cases described by Stockman et al. showed osteoclast-like giant cells