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Table 1 Previously reported cases of malignant gastrointestinal neuroectodermal tumor

From: Malignant gastrointestinal neuroectodermal tumor: a case report and review of the literature

 

Report

Age (years)/ Sex

Location

Morphology

S100

HMB-45 and Melan A

EM

Genetic finding

Outcome

Additional findings

1

Zambrano et al. [2]

15/F

Small intestine

Oval, spindled

+

-

No melanosomes

t(12;22) (q13;q12)

DOD at 16 months

OLGC

2

21/F

Small intestine

Oval, spindled

+

-

ND

ND

DOD at 12 months

OLGC

3

35/F

Small intestine

Oval, spindled

+

-

No melanosomes

ND

LN and liver metastasis at 12 months

OLGC

4

37/F

Small intestine

Oval, spindled

+

-

 

ND

NA

OLGC

5

13/M

Stomach

Oval, spindled

+

-

No melanosomes

ND

recurrences at 12 months

OLGC

6

32/M

Small intestine

Oval, spindled

+

-

ND

ND

LN mets

OLGC

7

Stockman et al. [1]a

30/F

Jejunum

Epithelioid

+

-

Dense-core granules

EWSR1-ATF1

AWD at 21 months

 

8

35/M

Jejunum

Epithelioid

+

-

Dense-core granules

EWSR1-ATF1

DOD at 18 months

 

9

33/M

Ileum

Epithelioid

+

-

Dense-core granules

EWSR1-CREB1

AWD at 1.5 months

 

10

50/F

Stomach

Epithelioid

+

-

Dense-core granules

EWSR1-ATF1

AWD at 24 months

 

11

20/F

Small intestine

Spindled

+

-

Dense-core granules

EWSR1

NED at 20 months

 

12

52/M

Ileum

Epithelioid

+

-

ND

-

DOD at 22 months

 

13

46/M

Stomach

Epithelioid

+

-

ND

EWSR1

NA

 

14

34/F

Stomach

Epithelioid, Spindled

+

-

ND

EWSR1-ATF1

DOD at 19 months

 

15

37/F

Ileum

Epithelioid

+

ND

ND

ND

NA

 

16

77/F

Colon

Epithelioid, Spindled

+

-

ND

EWSR1-ATF1

DOD at 106 months

 

17

31/M

Colon

Epithelioid

+

-

ND

-

DOD at 3 months

 

18

17/M

Small intestine

Epithelioid

+

-

ND

EWSR1

NA

 

19

60/M

Iluem

Epithelioid

+

-

ND

EWSR1-ATF1

AWD at 36 months

 

20

60/F

Jejunum

Epithelioid, Spindled

+

-

ND

EWSR1-CREB1

NED at 41 months

 

21

56/M

Stomach

Epithelioid

+

-

ND

EWSR1-CREB1

NA

 

22

28/F

Small intestine

Epithelioid

+

-

ND

EWSR1

DOD at 23 months

 

23

Insabato et al. [6]

29/M

Stomach

Epithelioid, spindled

+

-

No melanosomes

EWSR1

AWD at 74 months

Hx of Ewing sarcoma, FLI-1+

24

Zhao et al. [7]

33/F

Ileum

Epithelioid

+

-

 

EWSR1

NA

 

25

Kong et al. [5]

17/M

Stomach

Spindled, round

+

-

ND

EWSR1

NED at 10 months

OLGC

26

Huang et al. [3]

40/M

Stomach

Spindled, oval

+

-

ND

ND

LN mets at diagnosis

OLGC

27

Thway et al. [8]

33/M

Small intestine

Epithelioid, spindled

+

-

ND

EWSR1-CREB1

DOD at 7 months

Hx of hepato-blastoma

28

Friedrichs et al. [4]

41/M

Small intestine

Epithelioid

+

-

ND

t(12;22) (q13;q12)

Liver mets at 6 months

OLGC

29

Boland et al. [9]

46/F

Stomach

Epithelioid

+

-

ND

EWSR1-ATF1

NA

Oncocytic change

  1. AWD alive with disease, DOD dead of disease, EM electron microscopy, Hx history, mets, metastasis, NA not available, NED no evidence of disease, ND not done, OLGC osteoclast-like giant cells
  2. aEight cases described by Stockman et al. showed osteoclast-like giant cells