Table 1 Relationship between NDRG2 promoter methylation, patient clinical characteristics, PA invasiveness and NDRG2 mRNA expression
From: N-myc downstream-regulated gene 2 (NDRG2) promoter methylation and expression in pituitary adenoma
| NDRG2 gene methylation | ||||
|---|---|---|---|---|
| Number of patients | M (%) | U (%) | p-value | |
| Cases | 119 | 27 (22.69) | 92 (77.31) | |
| Age (years) | ||||
| ≤60 | 48 | 13 (27.08) | 35 (72.92) | 0.368 |
| >60 | 70 | 14 (20.00) | 56 (80.00) | |
| Gender | ||||
| Female | 68 | 15 (22.06) | 53 (77.94) | 0.850 |
| Male | 51 | 12 (23.53) | 39 (76.47) | |
| PA function | ||||
| Secreting | 61 | 15 (24.59) | 46 (75.41) | 0.612 |
| Non-secreting | 58 | 12 (20.69) | 46 (79.31) | |
| Relapse | ||||
| Appear | 10 | 2 (20.00) | 8 (80.00) | 0.832 |
| None | 109 | 25 (22.94) | 84 (77.06) | |
| Prolactinoma | ||||
| Appear | 37 | 9 (24.32) | 28 (75.68) | 0.952 |
| None | 24 | 6 (25.00) | 18 (75.00) | |
| Acromegaly | ||||
| Appear | 12 | 4 (33.33) | 8 (66.67) | 0.433 |
| None | 49 | 11 (22.45) | 38 (77.55) | |
| Cushing syndrome | ||||
| Appear | 1 | 0 (0.00) | 1 (100.00) | 0.565 |
| None | 60 | 15 (25.00) | 45 (75.00) | |
| Hormones | ||||
| PRL | 37 | 9 (24.32) | 28 (75.68) | 0.801 |
| IGF-1 | 2 | 0 (0.00) | 2 (100.00) | 0.401 |
| GH | 6 | 2 (33.33) | 4 (66.67) | 0.639 |
| ACTH | 1 | 0 (0.00) | 1 (100.00) | 0.556 |
| Multiple | 13 | 4 (30.77) | 9 (69.23) | 0.616 |
| Invasiveness | ||||
| Invasive | 41 | 10 (24.39) | 31 (75.61) | 0.452 |
| Non-invasive | 19 | 3 (15.79) | 16 (84.21) | |
| NDRG2 mRNA expression | ||||
| Low | 22 | 3 (13.64) | 19 (86.36) | |
| Medium | 50 | 13 (26.00) | 37 (74.00) | 0.458 |
| High | 37 | 7 (18.92) | 30 (81.08) | |