Skip to main content
Fig. 2 | Diagnostic Pathology

Fig. 2

From: Case report: ACTH-secreting pituitary carcinoma metastatic to the liver in a patient with a history of atypical pituitary adenoma and Cushing’s disease

Fig. 2

Histology of the APA and pituitary carcinoma. Hematoxylin and eosin (H&E) stain of the recurrent sellar-region APA demonstrating mildly pleomorphic polygonal cells with distinct nucleoli (a). Immunohistochemical staining for Ki-67 yielded a proliferation index of 8 to 15% (b). H&E stained views of the metastatic pituitary carcinoma, with the carcinoma labeled “PC” and surrounding benign liver labeled “L” for reference (c, d). Note the similar histologic appearance to the recurrent sellar lesion above. Mitotic activity was not conspicuous and necrosis was not present in any of the three lesions. Immunostains for synaptophysin (e), ACTH (f) and p53 (g) all demonstrated diffuse immunoreactivity in the metastatic lesional cells. Ki-67 was positive in approximately 10% of tumor nuclei overall, with focal areas approaching 20% immunostaining (h). Original magnifications: a, 600×; b, 200×; c, 100×; d, 600×; and e–h, 200x

Back to article page

Diagnostic Pathology

ISSN: 1746-1596

Contact us