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Table 2 The top 15 significantly enriched pathways for differentially expressed genes in CAD

From: A comparison of gene expression profiles in patients with coronary artery disease, type 2 diabetes, and their coexisting conditions

KEGG ID KEGG term Count FDR Genes
hsa04062 Chemokine signaling pathway 15 8.37E-06 STAT2,CCL3L3,NRAS,RAP1A,CXCL1,RAP1B,CCL3,GNAI3,IL8,ADCY4,PIK3R1,PTK2,CCL4,JAK2,PRKACB
hsa05144 Malaria 8 2.26E-05 IL1B,IL6,HBD,SDC4,GYPC,THBS1,IL8,ICAM1
hsa04670 Leukocyte transendothelial migration 10 2.07E-04 MLLT4,RAP1A,RAP1B,GNAI3,ARHGAP5,ICAM1,PIK3R1,PTK2,ITGB1,MYL12A
hsa04621 NOD-like receptor signaling pathway 7 4.20E-04 IL1B,NLRP1,IL6,TNFAIP3,CXCL1,BIRC3,IL8
hsa05142 Chagas disease (American trypanosomiasis) 9 4.85E-04 IL1B,IL6,CCL3L3,PPP2R2A,CCL3,GNAI3,IL8,IFNGR1,PIK3R1
hsa05323 Rheumatoid arthritis 8 4.86E-04 IL1B,IL6,ATP6V1C1,CCL3L3,CXCL1,CCL3,IL8,ICAM1
hsa04010 MAPK signaling pathway 14 4.97E-04 IL1B,NRAS,RAP1A,RASA2,PPM1A,LAMTOR3,RAP1B,PLA2G6,DUSP5,NR4A1,CACNB3,DUSP2,PRKACB,MAP3K8
hsa03010 Ribosome 8 5.05E-04 RPS3A,UBA52,RSL24D1,RPL7,RPL39,RPL21,RPS24,RPS12
hsa05146 Amoebiasis 8 1.26E-03 IL1B,IL6,CXCL1,SERPINB2,IL8,PIK3R1,PTK2,PRKACB
hsa04510 Focal adhesion 11 1.31E-03 PTEN,RAP1A,THBS1,BIRC3,RAP1B,ITGA5,ARHGAP5,PIK3R1,PTK2,ITGB1,MYL12A
hsa05162 Measles 9 1.33E-03 IL1B,IL6,STAT2,TBK1,TNFAIP3,IFNGR1,PIK3R1,JAK2,OAS1
hsa04620 Toll-like receptor signaling pathway 8 1.43E-03 IL1B,IL6,TBK1,CCL3,IL8,PIK3R1,CCL4,MAP3K8
hsa05222 Small cell lung cancer 7 2.02E-03 BCL2L1,PTEN,BIRC3,PIK3R1,PTK2,ITGB1,PTGS2
hsa04210 Apoptosis 7 2.17E-03 IL1B,BCL2L1,BIRC3,PIK3R1,IRAK3,PRKACB,ATM
hsa05145 Toxoplasmosis 8 3.37E-03 BCL2L1,BIRC3,PLA2G6,GNAI3,IFNGR1,PIK3R1,ITGB1,JAK2