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Fig. 2 | Diagnostic Pathology

Fig. 2

From: GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15

Fig. 2

The invasive adenocarcinoma in type Ib disease (primary extramammary Paget disease with invasive adenocarcinoma) (A1: vulva, with intracytoplasmic mucin; B1: scrotum) showed positive GATA3 staining in all but one cases (A2, B2) (A2 also with intraepithelial disease). Most of such invasive adenocarcinomas were also positive for GCDFP15 staining (A3, B3). All 3 metastatic adenocarcinomas from vulvar (C1) and 11 of 12 metastatic adenocarcinomas from penoscrotal (D1) extramammary Paget diseases were positive for GATA3 (C2, D2) and most of them were also positive for GCDFP15 (C3, D3). GATA3 stains more tumor cells than GCDFP15 in some cases (D2, D3)

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Diagnostic Pathology

ISSN: 1746-1596

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