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Fig. 3 | Diagnostic Pathology

Fig. 3

From: GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15

Fig. 3

Immunohistochemical staining of GATA3 and GCDFP15 in a vulvar primary extra-mammary Paget disease with an underlying apocrine adenocarcinoma (type Ic disease). The underlying apocrine adenocarcinoma formed a mass in the dermis and subcutaneous tissue but it eroded the epidermis (a) and grew in a pagetoid pattern within the adjacent epidermis (b, g). The underlying adenocarcinoma showed nests, solid and glandular growth patterns with some cribriform glands (c, d). Cytoplasmic apical apocrine snouts were apparent (d). Both the underlying invasive apocrine adenocarcinoma (d) and the overlying intraepithelial Paget disease (g) were positive for GATA3 (e, h) and GCDFP15 (f, i). Similar GATA3 findings were also observed in penoscrotal type Ic diseases

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Diagnostic Pathology

ISSN: 1746-1596

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