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Table 1 Immunohistochemical staining results of GATA3 and GCDFP15 in primary vulvar extramammary Paget diseases

From: GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15

Disease Component

GATA3 staininga

 

GCDFP15 staininga

 

P value

0

1+

2+

3+

4+

Total

0

1+

2+

3+

4+

Total

Intraepithelial disease (N = 34)

0

2 (6%)

1 (3%)

3 (9%)

28 (82%)

34 (100%)

6 (8%)

12 (35%)

4 (12%)

4 (12%)

8 (24%)

28 (82%)

0.0004#

 Type Ia (N = 24)

 

1

 

3

20

4

8

4

3

5

  

 Type Ib (N = 5)

  

1

 

4

1

3

  

1

  

 Type Ic (N = 5)

 

1

  

4

1

1

 

1

2

  

Invasive adenocarcinoma(N = 10)

0

0

2 (20%)

0

8 (80%)

10 (10%)

1 (10%)

3 (30%)

0

1 (10%)

5 (50%)

9 (90%)

0.1035#

 type Ib (N = 5)

    

5

  

1

 

1

3

  

 type Ic (N = 5)

  

2

 

3

 

1

2

  

2

  

Metastatic adenocarcinoma (N = 3)

0

0

0

0

3 (100%)

3 (100%)

1 (33%)

1 (33%)

0

0

1 (33%)

2 (67%)

not applicable

  1. aThe staining is semi-quantitatively as follows: 0: <1% tumor cell staining; 1+: 1–25% tumor cells staining; 2+: 26–50% tumor cells staining; 3+: 51–75% tumor cells staining; 4+: 76–100% tumor cells staining. NA non-applicable due to small number
  2. # p value refers to comparison of staining patterns (0,1+,2+,3+,4+) not percentage of total positives