GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15

Table 2 Immunohistochemical staining results of GATA3 and GCDFP15 in primary male genital extramammary Paget diseases

Disease Component	GATA3 staining^a						GCDFP15 staining^a						P value
	0	1+	2+	3+	4+	Total	0	1+	2+	3+	4+	Total
Intraepithelial disease (N = 37)	0	4 (11%)	2 (6%)	2 (6%)	29 (78%)	37 (100%)	19 (51%)	12 (32%)	4 (11%)	0	2 (6%)	18 (49%)	< 0.001
Type Ia (N = 21)		1			20		17	4
Type Ib (N = 14)		3	1	2	8		1	7	4		2
Type Ic (N = 2)			1		1		1	1
Invasive adenocarcinoma (N = 16)	1 (6%)	2 (13%)	2 (13%)	1 (6%)	10 (63%)	15 (94%)	5 (31%)	6 (38%)	1 (6%)	0	4 (25%)	11 (69%)	0.062
type Ib (N = 14)	1	2	1	1	9		5	5			4
type Ic (N = 2)			1		1			1	1
Metastatic adenocarcinoma (N = 12)	1 (8%)	1 (8%)	1 (8%)	1 (8%)	8 (67%)	11 (92%)	2 (17%)	3 (25%)	2 (17%)	1 (8%)	4 (33%)	10 (83%)	0.277

^aThe staining is semi-quantitatively scored as follows: 0: < 1% tumor cell staining; 1+: 1–25% tumor cells staining; 2+: 26–50% tumor cells staining; 3+: 51–75% tumor cells staining; 4+: 76–100% tumor cells staining

ISSN: 1746-1596