Level of mitoses in non-muscle invasive papillary urothelial carcinomas (pTa and pT1) at initial bladder biopsy is a simple and powerful predictor of clinical outcome: a multi-center study in South Korea

Table 3 Univariate analysis of factors associated with recurrence of PUC-Ta

Variable	Category	Odds ratio	95% Confidence Interval	P-value
Age		1.00	0.97-1.03	0.9401
Sex	man vs. woman	1.11	0.50-2.47	0.7908
No of tumor		0.34	0.17-0.67	0.0021*
Size of tumor		2.27	1.05-5.07	0.0399*
Papillary fusion	2 vs 1	1.50	0.65-3.50	0.3430
Papillary fusion	3 vs 1	1.60	0.74-3.50	0.2348
Umbrella cell	2 vs. 1	0.95	0.44-2.07	0.9020
Umbrella cell	3 vs. 1	1.19	0.52-2.75	0.6723
Discohesiveness	2 vs. 1	1.93	0.80-4.78	0.1480
Discohesiveness	3 vs. 1	1.57	0.71-3.53	0.2682
Cell density	2 vs. 1	1.62	0.69-3.88	0.2737
Cell density	3 vs. 1	0.88	0.37-2.08	0.7719
Nuclear pleomorphism	2 vs. 1	0.47	0.21-1.03	0.0621
	3 vs. 1	0.39	0.14-1.03	0.0599
	4 vs. 1	3.84	0.58-76.11	0.2324
Multinucleated giant cell	1 vs. 0	1.14	0.58-2.24	0.7041
Loss of polarity	2 vs. 1	1.03	0.41-2.59	0.9557
Loss of polarity	3 vs. 1	0.82	0.29-2.26	0.6981
Hyperchromasia	2 vs. 1	1.36	0.67-2.79	0.3904
Hyperchromasia	3 vs. 1	0.97	0.26-3.47	0.9604
Nuclear groove	2 vs. 1	1.83	0.86-3.96	0.1184
Nuclear groove	3 vs. 1	1.60	0.65-3.99	0.3079
Prominent nucleoli	2 vs. 1	1.12	0.56-2.23	0.7491
Prominent nucleoli	3 vs. 1	0.81	0.15-3.90	0.7903
Whorling pattern	1 vs. 0	1.07	0.55-2.11	0.8327
Necrosis	2 vs 1	0.98	0.39-2.48	0.9694
	3 vs 1	0.77	0.21-2.58	0.6680
	4 vs 1	1.47	0.54-4.14	0.4490
Divergent histology		2.04	0.73-8.10	0.2172
Mitotic count		1.03	1.00-1.07	0.0468*
Mitotic count (CAT)	2 vs. 1	4.62	1.89-11.98	0.0011
	3 vs. 1	2.52	0.94-6.95	0.0684
	4 vs. 1	3.15	1.22-8.46	0.0193*
Mitotic level	2 vs. 1	2.13	0.83-5.70	0.1229
Mitotic level	3 vs. 1	4.44	1.88-11.18	0.0010*
Apoptosis	2 vs 1	1.15	0.53-2.50	0.7246
Apoptosis	3 vs 1	1.09	0.24-4.82	0.9116
Capillary proliferation		1.05	1.01-1.10	0.0136*

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