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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Identification and in silico characterization of p.G380R substitution in FGFR3, associated with achondroplasia in a non-consanguineous Pakistani family

Fig. 3

Structure modeling: (a) PsiPred results showing number of secondary structure features in the wild-type and mutant forms of FGFR3. b Three-dimensional structure prediction of wild-type FGFR3 using I-Tasser. Red cylinders showing α-helix, flattened cyan color arrows showing β-Sheets and rest tube like features are coils. c Superimposed three-dimensional structures of wild-type and mutant highlighting the substituted amino acid. Superimposed structures represented by purple wire display style while red ball & stick model is representing arginine which got substituted by glycine (green color stick display style) at 380 amino acid position (p.G380R)

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