Characteristics | Â | No. | NGF | Â | HO1 | Â | NGF/HO1 expression pattern | Â | ||
---|---|---|---|---|---|---|---|---|---|---|
 |  |  | Positive | p | Positive | p | −/− | −/+ or +/− | +/+ | p |
Age, years | <60 | 50 | 11 (22%) | 0.002 | 18 (36%) | 0.012 | 30 (60%) | 11 (22%) | 9 (18%) | <0.001 |
 | ≥60 | 117 | 56 (48%) |  | 67 (57%) |  | 30 (26%) | 51 (44%) | 36 (31%) |  |
Sex | Female | 41 | 12 (29%) | 0.103 | 34 (83%) | <0.001 | 7 (17%) | 22 (54%) | 12 (29%) | 0.009 |
 | Male | 126 | 55 (44%) |  | 51 (40%) |  | 53 (42%) | 40 (32%) | 33 (26%) |  |
CEAa | Normal | 107 | 40 (37%) | 0.358 | 56 (52%) | 0.232 | 39 (36%) | 40 (37%) | 28 (26%) | 0.944 |
 | Elevated | 30 | 14 (47%) |  | 12 (40%) |  | 11 (37%) | 12 (40%) | 7 (23%) |  |
CA19-9a | Normal | 121 | 47 (39%) | 0.392 | 60 (50%) | 0.975 | 44 (36%) | 47 (39%) | 30 (25%) | 0.843 |
 | Elevated | 16 | 8 (50%) |  | 8 (50%) |  | 5 (31%) | 6 (38%) | 5 (31%) |  |
Tumor stage | I & II | 77 | 27 (35%) | 0.218 | 34 (46%) | 0.107 | 33 (43%) | 27 (35%) | 17 (24%) | 0.189 |
 | III & IV | 90 | 40 (44%) |  | 51 (55%) |  | 27 (30%) | 35 (39%) | 28 (31%) |  |
Tumor invasion | EGC | 33 | 10 (30%) | 0.199 | 16 (48%) | 0.757 | 15 (45%) | 10 (30%) | 8 (24%) | 0.435 |
 | AGC | 134 | 57 (43%) |  | 69 (51%) |  | 45 (34%) | 52 (39%) | 37 (28%) |  |
Lymph node metastasis | Absence | 57 | 18 (32%) | 0.105 | 26 (46%) | 0.325 | 25 (44%) | 20 (35%) | 12 (21%) | 0.256 |
 | Presence | 110 | 49 (45%) |  | 59 (54%) |  | 35 (32%) | 42 (38%) | 33 (30%) |  |
Venous invasion | Absence | 137 | 53 (39%) | 0.419 | 71 (52%) | 0.609 | 51 (37%) | 48 (35%) | 38 (28%) | 0.489 |
 | Presence | 30 | 14 (47%) |  | 14 (47%) |  | 9 (30%) | 14 (47%) | 7 (23%) |  |
WHO classification | Tubular | 115 | 54 (47%) | 0.011 | 65 (57%) | 0.052 | 33 (29%) | 45 (39%) | 37 (32%) | 0.010 |
 | Signet ring cell | 18 | 2 (11%) |  | 8 (44%) |  | 10 (56%) | 6 (33%) | 2 (11%) |  |
 | Mucinous | 17 | 4 (24%) |  | 4 (24%) |  | 9 (53%) | 8 (47%) | 0 (0%) |  |
 | Mixed | 13 | 5 (38%) |  | 6 (46%) |  | 6 (46%) | 3 (23%) | 4 (31%) |  |
 | Papillary | 2 | 2 (100%) |  | 2 (100%) |  | 0 (0%) | 0 (0%) | 2 (100%) |  |
 | Neuroendocrine | 2 | 0 (0%) |  | 0 (0%) |  | 2 (100%) | 0 (0%) | 0 (0%) |  |
Histologic gradeb | WD | 11 | 5 (45%) | 0.326 | 7 (64%) | 0.803 | 4 (36%) | 2 (18%) | 5 (45%) | 0.433 |
 | MD | 65 | 35 (54%) |  | 38 (58%) |  | 15 (23%) | 27 (42%) | 23 (35%) |  |
 | PD | 41 | 16 (39%) |  | 22 (54%) |  | 14 (34%) | 16 (39%) | 11 (27%) |  |
Lauren classification | Intestinal | 75 | 34 (45%) | 0.010 | 44 (59%) | 0.154 | 22 (29%) | 28 (37%) | 25 (33%) | 0.226 |
 | Diffuse | 71 | 20 (28%) |  | 33 (46%) |  | 32 (45%) | 25 (35%) | 14 (20%) |  |
 | Mixed | 21 | 13 (62%) |  | 8 (38%) |  | 6 (29%) | 9 (43%) | 6 (29%) |  |
HO1 | Negative | 82 | 22 (27%) | <0.001 | Â | Â | Â | Â | Â | Â |
 | Positive | 85 | 45 (53%) |  |  |  |  |  |  |  |