Skip to main content

Table 1 Clinicopathologic variables and the expression of NGF and HO1 in 167 gastric carcinomas

From: Individual and co-expression patterns of nerve growth factor and heme oxygenase-1 predict shorter survival of gastric carcinoma patients

Characteristics

 

No.

NGF

 

HO1

 

NGF/HO1 expression pattern

 
   

Positive

p

Positive

p

−/−

−/+ or +/−

+/+

p

Age, years

<60

50

11 (22%)

0.002

18 (36%)

0.012

30 (60%)

11 (22%)

9 (18%)

<0.001

 

≥60

117

56 (48%)

 

67 (57%)

 

30 (26%)

51 (44%)

36 (31%)

 

Sex

Female

41

12 (29%)

0.103

34 (83%)

<0.001

7 (17%)

22 (54%)

12 (29%)

0.009

 

Male

126

55 (44%)

 

51 (40%)

 

53 (42%)

40 (32%)

33 (26%)

 

CEAa

Normal

107

40 (37%)

0.358

56 (52%)

0.232

39 (36%)

40 (37%)

28 (26%)

0.944

 

Elevated

30

14 (47%)

 

12 (40%)

 

11 (37%)

12 (40%)

7 (23%)

 

CA19-9a

Normal

121

47 (39%)

0.392

60 (50%)

0.975

44 (36%)

47 (39%)

30 (25%)

0.843

 

Elevated

16

8 (50%)

 

8 (50%)

 

5 (31%)

6 (38%)

5 (31%)

 

Tumor stage

I & II

77

27 (35%)

0.218

34 (46%)

0.107

33 (43%)

27 (35%)

17 (24%)

0.189

 

III & IV

90

40 (44%)

 

51 (55%)

 

27 (30%)

35 (39%)

28 (31%)

 

Tumor invasion

EGC

33

10 (30%)

0.199

16 (48%)

0.757

15 (45%)

10 (30%)

8 (24%)

0.435

 

AGC

134

57 (43%)

 

69 (51%)

 

45 (34%)

52 (39%)

37 (28%)

 

Lymph node metastasis

Absence

57

18 (32%)

0.105

26 (46%)

0.325

25 (44%)

20 (35%)

12 (21%)

0.256

 

Presence

110

49 (45%)

 

59 (54%)

 

35 (32%)

42 (38%)

33 (30%)

 

Venous invasion

Absence

137

53 (39%)

0.419

71 (52%)

0.609

51 (37%)

48 (35%)

38 (28%)

0.489

 

Presence

30

14 (47%)

 

14 (47%)

 

9 (30%)

14 (47%)

7 (23%)

 

WHO classification

Tubular

115

54 (47%)

0.011

65 (57%)

0.052

33 (29%)

45 (39%)

37 (32%)

0.010

 

Signet ring cell

18

2 (11%)

 

8 (44%)

 

10 (56%)

6 (33%)

2 (11%)

 
 

Mucinous

17

4 (24%)

 

4 (24%)

 

9 (53%)

8 (47%)

0 (0%)

 
 

Mixed

13

5 (38%)

 

6 (46%)

 

6 (46%)

3 (23%)

4 (31%)

 
 

Papillary

2

2 (100%)

 

2 (100%)

 

0 (0%)

0 (0%)

2 (100%)

 
 

Neuroendocrine

2

0 (0%)

 

0 (0%)

 

2 (100%)

0 (0%)

0 (0%)

 

Histologic gradeb

WD

11

5 (45%)

0.326

7 (64%)

0.803

4 (36%)

2 (18%)

5 (45%)

0.433

 

MD

65

35 (54%)

 

38 (58%)

 

15 (23%)

27 (42%)

23 (35%)

 
 

PD

41

16 (39%)

 

22 (54%)

 

14 (34%)

16 (39%)

11 (27%)

 

Lauren classification

Intestinal

75

34 (45%)

0.010

44 (59%)

0.154

22 (29%)

28 (37%)

25 (33%)

0.226

 

Diffuse

71

20 (28%)

 

33 (46%)

 

32 (45%)

25 (35%)

14 (20%)

 
 

Mixed

21

13 (62%)

 

8 (38%)

 

6 (29%)

9 (43%)

6 (29%)

 

HO1

Negative

82

22 (27%)

<0.001

      
 

Positive

85

45 (53%)

       
  1. Abbreviations: EGC early gastric cancer, AGC advanced gastric cancer, WD well differentiated, MD moderately differentiated, PD poorly differentiated
  2. aThe data for the serum levels of CEA and CA19-9 were available in 137 and 137 patients, respectively
  3. bHistologic grading was carried in tubular and papillary type carcinomas according to the grading system of the WHO histological classification of gastric tumors