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Table 1 Clinicopathologic variables and the expression of NGF and HO1 in 167 gastric carcinomas

From: Individual and co-expression patterns of nerve growth factor and heme oxygenase-1 predict shorter survival of gastric carcinoma patients

Characteristics   No. NGF   HO1   NGF/HO1 expression pattern  
    Positive p Positive p −/− −/+ or +/− +/+ p
Age, years <60 50 11 (22%) 0.002 18 (36%) 0.012 30 (60%) 11 (22%) 9 (18%) <0.001
  ≥60 117 56 (48%)   67 (57%)   30 (26%) 51 (44%) 36 (31%)  
Sex Female 41 12 (29%) 0.103 34 (83%) <0.001 7 (17%) 22 (54%) 12 (29%) 0.009
  Male 126 55 (44%)   51 (40%)   53 (42%) 40 (32%) 33 (26%)  
CEAa Normal 107 40 (37%) 0.358 56 (52%) 0.232 39 (36%) 40 (37%) 28 (26%) 0.944
  Elevated 30 14 (47%)   12 (40%)   11 (37%) 12 (40%) 7 (23%)  
CA19-9a Normal 121 47 (39%) 0.392 60 (50%) 0.975 44 (36%) 47 (39%) 30 (25%) 0.843
  Elevated 16 8 (50%)   8 (50%)   5 (31%) 6 (38%) 5 (31%)  
Tumor stage I & II 77 27 (35%) 0.218 34 (46%) 0.107 33 (43%) 27 (35%) 17 (24%) 0.189
  III & IV 90 40 (44%)   51 (55%)   27 (30%) 35 (39%) 28 (31%)  
Tumor invasion EGC 33 10 (30%) 0.199 16 (48%) 0.757 15 (45%) 10 (30%) 8 (24%) 0.435
  AGC 134 57 (43%)   69 (51%)   45 (34%) 52 (39%) 37 (28%)  
Lymph node metastasis Absence 57 18 (32%) 0.105 26 (46%) 0.325 25 (44%) 20 (35%) 12 (21%) 0.256
  Presence 110 49 (45%)   59 (54%)   35 (32%) 42 (38%) 33 (30%)  
Venous invasion Absence 137 53 (39%) 0.419 71 (52%) 0.609 51 (37%) 48 (35%) 38 (28%) 0.489
  Presence 30 14 (47%)   14 (47%)   9 (30%) 14 (47%) 7 (23%)  
WHO classification Tubular 115 54 (47%) 0.011 65 (57%) 0.052 33 (29%) 45 (39%) 37 (32%) 0.010
  Signet ring cell 18 2 (11%)   8 (44%)   10 (56%) 6 (33%) 2 (11%)  
  Mucinous 17 4 (24%)   4 (24%)   9 (53%) 8 (47%) 0 (0%)  
  Mixed 13 5 (38%)   6 (46%)   6 (46%) 3 (23%) 4 (31%)  
  Papillary 2 2 (100%)   2 (100%)   0 (0%) 0 (0%) 2 (100%)  
  Neuroendocrine 2 0 (0%)   0 (0%)   2 (100%) 0 (0%) 0 (0%)  
Histologic gradeb WD 11 5 (45%) 0.326 7 (64%) 0.803 4 (36%) 2 (18%) 5 (45%) 0.433
  MD 65 35 (54%)   38 (58%)   15 (23%) 27 (42%) 23 (35%)  
  PD 41 16 (39%)   22 (54%)   14 (34%) 16 (39%) 11 (27%)  
Lauren classification Intestinal 75 34 (45%) 0.010 44 (59%) 0.154 22 (29%) 28 (37%) 25 (33%) 0.226
  Diffuse 71 20 (28%)   33 (46%)   32 (45%) 25 (35%) 14 (20%)  
  Mixed 21 13 (62%)   8 (38%)   6 (29%) 9 (43%) 6 (29%)  
HO1 Negative 82 22 (27%) <0.001       
  Positive 85 45 (53%)        
  1. Abbreviations: EGC early gastric cancer, AGC advanced gastric cancer, WD well differentiated, MD moderately differentiated, PD poorly differentiated
  2. aThe data for the serum levels of CEA and CA19-9 were available in 137 and 137 patients, respectively
  3. bHistologic grading was carried in tubular and papillary type carcinomas according to the grading system of the WHO histological classification of gastric tumors