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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Localized amyloidosis of the epididymis: a previously unreported phenomenon

Fig. 3

Relationship between intratubular and interstitial amyloid deposits (a to d), and detection of amyloids in normal epididymis (e to g). a: Epithelium-lined (arrow) (intraluminal) and non-epithelium-lined (interstitial) zones of an amyloid deposit are observed in continuity. b: A reticulin network in the interstitial zone but not in the luminal zone of the amyloid deposit is observed. c to e: Epithelial folds with degenerative phenomena are observed surrounding small portions of intraluminal amyloid deposits, which are partially incorporated in the interstitium. In normal epididymis, expression of transthyretin (f) and amyloid P (g) is observed in the apical surface of the epididymal epithelium. Strong expression of amyloid P is also shown in spermatozoa (g and h). a: transthyretin immunostaining. c and d: H&E staining. e: pan CK AE1 AE·immunostaining. a, b, e and f: ×120; c and d: ×320; g and h: ×340

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