Table 1 Summary of clinical data and detected gene mutations in the past reports and present cases
From: Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation
Author | Age (median) | Sex (M/F) | smoking habit (Y/N) | Driver Mutation | Other Mutations | NGS panel |
|---|---|---|---|---|---|---|
Kamata et al. [4] | 62 | 7/3 | 5/5 | BRAF V600E, 4 cases; EGFR ex19del E746-T751, 3 cases; BRAF G606R, 1 case | IDH1 G123R, 1 case; CTNNB1 D32N, 1 case; PTPN11 E76K, 1 case; PTPN11 P491L, 1 case; TP53 L289F, 1 case | Ion AmpliSeq Cancer Hotspot Panel v2 |
Liu et al. [5] | – | 1/3 | – | BRAF V600E, 1 case | AKT1 E17K, 1 case | Ion AmpliSeq Cancer Hotspot Panel v2 |
Lau et al. [15] | 19 | 0/1 | 0/1 | none | none | Ion Ampliseq Colon and lung cancer panel |
Our series | 67 | 0/4 | 0/4 | BRAF V600E 1 caseKRAS G12D, 1 case | AKT1 E17K, 1 case | Ion AmpliSeq Cancer Hotspot Panel v2; The Contextual Genomics Find-ItTM test |