Fig. 2
From: Primary paranasal sinus hyalinizing clear cell carcinoma: a case report
Histological features of HCCC and FISH analysis. a - c, scanning magnification showing an infiltrative clear cell tumour associated with bone destruction (a, H&E, original magnification 40×), these polygonal to round clear cells are arranged in nests separated by hyalinized fibrocellular septa. Other smaller cells with eosinophilic cytoplasm are seen mostly at the periphery of the tumour (b, hematoxylin and eosin, original magnification 200×). Nuclei are round and central (c, hematoxylin and eosin, original magnification 200×). Diffuse cytoplasmic and membranous staining for CK5/6 (d, immunohistochemistry, original magnification 200×). FISH analysis using dual-color, EWSR1 break apart probe. The tumour cells show one green and one red signal, indicative of a rearrangement of EWSR1 region (e)