Composite intestinal adenoma-microcarcinoid in the colon and rectum: a case series and historical review

Diagnostic Pathology

Table 1 Clinicopathologic features of the present study

Case	Age (yrs) / Sex	Location of polyp	Procedure	Polyp size (mm)	Histology of glandular component	Initial diagnosis	Size of micro-carcinoid (mm)	SYN	CHR
1	76/F	Ascending colon	ESD	18	IMAC, WD	IMAC, WD	2	+	+
2	68/M	Transverse colon	ESD	25	IMAC, WD	IMAC, WD	4	+	+
3	55/M	Splenic flexure	EMR	27	TA	TA with endocrine cell proliferation	3	+	+
4	65/F	Hepatic flexure	ESD	33	TA	TA	4	+	+
5	49/F	Sigmoid colon	EMR	18	TA	Composite TA and carcinoid tumor	5	+	–
6	74/F	Ascending colon	ESD	23	TVA, HGD	TVA, HGD, with microcarcinoid component	8	+	+
7	55/M	Ascending colon	EMR	10	TA	TA and microcarcinoid	2	+	+
8	47/F	Cecum	EMR	18	TVA	TVA and microcarcinoid	4	+	+
9	61/M	Hepatic flexure	RHC	17	TA	TA and microcarcinoid	2	+	+
10	68/M	Ascending colon	EMR	11	SIAC, WD	Adenocarcinoma, WD, with microcarcinoid component	5	+	+
11	59/M	Splenic flexure	Polypectomy	5	TA	TA and microcarcinoid	1	+	+
12	65/M	Rectum	ESD	20	TVA, HGD	TVA and microcarcinoid	2	+	–
13	78/M	Rectum	ESD	36	TVA, HGD	TVA and microcarcinoid	2	+	–
14	44/M	Sigmoid colon	ESD	17	TA, HGD	TA and microcarcinoid	3	+	+
15	56/F	Ascending colon	ESD	30	TA	TA and microcarcinoid	6	+	+
16	81/F	Rectosigmoid colon	EMR	11	TA	TA and microcarcinoid	2	+	–
17	57/F	Ascending colon	ESD	25	TA, HGD	TA and microcarcinoid	7	+	+
18	46/M	Ascending colon	Polypectomy	20	TVA	TVA and microcarcinoid	2	+	+
19	56/M	Hepatic flexure	Polypectomy	8	TA	TA and microcarcinoid	1	+	–
20	52/M	Rectum	ESD	127	TVA	TVA and microcarcinoid	4	+	–
21	73/M	Transverse colon	Polypectomy	12	TA	TA and microcarcinoid	4	+	+
22	78/F	Rectum	LAR	100	TVA, HGD	TVA and microcarcinoid	20	+	–
23	69/F	Ascending colon	ESD	28	TA	TA and microcarcinoid	13	+	+
24	57/F	Sigmoid colon	EMR	13	TA	TA and microcarcinoid	6	+	+

CHR chromogranin, EMR endoscopic mucosal resection, ESD endoscopic submucosal dissection, F female, HGD high-grade dysplasia, IMAC intramucosal adenocarcinoma, LAR low anterior resection, M male, RHC right hemicolectomy, SIAC submucosal invasive adenocarcinoma, SYN synaptophysin, TA tubular adenoma, TVA tubulovillous adenoma, WD well-differentiated

ISSN: 1746-1596