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Fig. 1 | Diagnostic Pathology

Fig. 1

From: p53 aberrations in low grade endometrioid carcinoma of the endometrium with nodal metastases: possible insights on pathogenesis discerned from immunohistochemistry

Fig. 1

Morphologic and immunophenotypic features of tumor in the uterus: a Focus of myometrial invasion (black arrow) with overlying endometrial tumor (blue arrow) (H and E, original magnification: 2 x). b The p53-wild type areas of the tumor (H and E, original magnification: 40X). c Transitional areas between myoinvasive glands (black arrow) and overlying, non-myoinvasive parts of tumor (blue arrow) (H and E, original magnification: 40X). d and e p53 immunohistochemistry showing wild-type staining pattern in the myoinvasive glands and aberrant staining pattern in the overlying, non-myoinvasive parts of tumor (original magnifications: 1D: 2X; 1E: 10X). f Loss of MSH2 in both components of the tumor (original magnification: 10×). g p16 immunohistochemistry showing mosaic staining pattern in the myoinvasive glands and diffuse staining pattern in the overlying, non-myoinvasive parts of tumor (original magnification: 10X). h Vimentin expression in both components of the tumor (original magnification: 10×). i Estrogen receptor expression in both components of the tumor (original magnification: 10×)

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