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Fig. 2 | Diagnostic Pathology

Fig. 2

From: p53 aberrations in low grade endometrioid carcinoma of the endometrium with nodal metastases: possible insights on pathogenesis discerned from immunohistochemistry

Fig. 2

Morphologic and immunophenotypic features of tumor in one lymph node. a-c The 2 components of the tumor (ie areas that were ultimately classified as p53 wild-type (black arrow) and p53-aberrant (gray arrow) were apposed but not intermixed. An red line approximately separates the 2 areas. [H and E, original magnification: 2 x (1A); 4× (1B); 10× (1C)]. d, g p53 immunohistochemistry, showing different patterns of expression in both areas of the tumor [original magnifications: 2 x (1D); 10× (1G)]. e, h p16 immunohistochemistry, showing different patterns of expression in both areas of the tumor [original magnifications: 2 x (1E); 10× (1H)]. f, i Progesterone receptor immunohistochemistry showing similar patterns of expression in both components [original magnifications: 2 x (1E); 10× (1H)]

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