Fig. 3

a Diagram of chromosomes 7 and 12 illustrating chromosomal breakpoints at location of BRAF (q34) and GIT2 (q24.11), respectively. b Schematic of BRAF gene, including autoregulatory domain (CR1) and kinase domain (CR3), and GIT2 gene. Breakpoints at intron 8 of BRAF and intron 14 of GIT2 are diagramed. c Resulting GIT2-BRAF fusion gene, with deletion of autoregulatory domain of BRAF. The kinase domain (CR3) is hypothesized to be constitutively activated in the resulting fusion protein (Additional file 1: Figure S1)