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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Sclerosing angiomatoid nodular transformation of the spleen in a patient with Maffucci syndrome: a case report and review of literature

Fig. 4

Microscopical features and immunohistochemistry of the pathological sections of the spleen. The Hematoxylin-Eosin staining ((a) H&E staining ×2; (b) H&E staining, ×200) shows multiple small nodules formed by proliferative spindle cells without obvious cellular atypia or mitotic figures. The immunostaining revealed 3 distinct types of vessels in the angiomatoid nodules: CD34−/CD8−/CD31+ small veins, CD34−/CD8+/CD31+ sinusoids, and CD34+/CD8−/CD31+ capillaries ((c) CD34 × 200; (d) CD8 × 200; (e)CD31 × 200). Some endothelial cells expressed CD68 while lacking staining of actin, desmin, S-100 and CD163 ((f) CD68 × 200; (g) CD163 × 200; (h) Actin; (i) Desmin; (j) S-100)

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Diagnostic Pathology

ISSN: 1746-1596

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