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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Composite neuroendocrine tumor and adenocarcinoma of the rectum

Fig. 2

Representative micrographs of the submucosal lesion. (a) Low-power view shows a typical neuroendocrine tumor (b), an atypical glandular component (c) and an admixture of the two components (d). The surface epithelium appears intact. b High-power view of the typical neuroendocrine tumor in the submucosal layer. This component is composed of uniform tumor cells with “salt-and-pepper” rounded nuclei and eosinophilic granular cytoplasm. c High-power view of the atypical glandular component in the submucosal layer. This component shows atypical epithelial cells with enlarged nuclei and coarse chromatin, forming irregular glands. At the periphery, trabeculae of endocrine cells are also evident. d Atypical glandular components show histologic transition to the typical neuroendocrine tumor component with a rosette-like or reticular growth pattern

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