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Table 1 Correlations between characteristics of nucleoli in malignant melanocytes and clinical parameters

From: Nucleoli cytomorphology in cutaneous melanoma cells – a new prognostic approach to an old concept

Clinical parameters

Characteristics of nucleoli

Size

Presence

Number

Low

High

p value

Low

High

p value

Low

High

p value

Age in years (21–79)a

mean, 57 ± 15.4; median, 58

  

0.463

  

0.883

  

0.480

Genderb

 Female

46

11

0.618

25

32

0.532

42

15

0.464

 Male

29

10

20

19

32

7

Primary tumor locationc

 Head/neck

10

4

0.927

5

9

0.295

11

3

0.722

 Extremities

33

8

20

21

30

11

 Hand/ft

2

1

0

3

3

0

 Trunk

30

8

20

18

30

8

Primary tumor (pT)a

 pT1

28

6

0.022

21

13

0.025

27

7

0.233

 pT2

17

0

10

7

15

2

 pT3

15

9

6

18

15

9

 pT4

15

6

8

13

17

4

Regional lymph nodes status (pN)b

 No metastases (pN-)

64

17

0.735

38

43

1.000

64

17

0.326

 Metastases present (pN+)

11

4

7

8

10

5

Distant metastases (pM)b

 No metastases (pM-)

71

20

1.000

44

48

0.363

72

19

0.076

 Metastases present (pM+)

4

1

1

4

2

3

Sentinel lymph node biopsy status (SNLB)b (55 patients)

 No metastases (SNLB-)

37

8

1.000

23

22

1.000

37

8

1.000

 Metastases present (SNLB+)

8

2

5

5

8

2

Recurrenceb

 No

64

18

1.000

39

43

0.778

63

19

1.000

 Yes

11

3

6

8

11

3

  1. a p value of Wilcoxon two sample test
  2. b p value of Fisher’s exact test
  3. c p value of chi2 test;
  4. Statistically significant results (P < 0.05) are in bold text