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Table 1 Correlations between characteristics of nucleoli in malignant melanocytes and clinical parameters

From: Nucleoli cytomorphology in cutaneous melanoma cells – a new prognostic approach to an old concept

Clinical parameters Characteristics of nucleoli
Size Presence Number
Low High p value Low High p value Low High p value
Age in years (21–79)a
mean, 57 ± 15.4; median, 58
   0.463    0.883    0.480
Genderb
 Female 46 11 0.618 25 32 0.532 42 15 0.464
 Male 29 10 20 19 32 7
Primary tumor locationc
 Head/neck 10 4 0.927 5 9 0.295 11 3 0.722
 Extremities 33 8 20 21 30 11
 Hand/ft 2 1 0 3 3 0
 Trunk 30 8 20 18 30 8
Primary tumor (pT)a
 pT1 28 6 0.022 21 13 0.025 27 7 0.233
 pT2 17 0 10 7 15 2
 pT3 15 9 6 18 15 9
 pT4 15 6 8 13 17 4
Regional lymph nodes status (pN)b
 No metastases (pN-) 64 17 0.735 38 43 1.000 64 17 0.326
 Metastases present (pN+) 11 4 7 8 10 5
Distant metastases (pM)b
 No metastases (pM-) 71 20 1.000 44 48 0.363 72 19 0.076
 Metastases present (pM+) 4 1 1 4 2 3
Sentinel lymph node biopsy status (SNLB)b (55 patients)
 No metastases (SNLB-) 37 8 1.000 23 22 1.000 37 8 1.000
 Metastases present (SNLB+) 8 2 5 5 8 2
Recurrenceb
 No 64 18 1.000 39 43 0.778 63 19 1.000
 Yes 11 3 6 8 11 3
  1. a p value of Wilcoxon two sample test
  2. b p value of Fisher’s exact test
  3. c p value of chi2 test;
  4. Statistically significant results (P < 0.05) are in bold text