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Table 2 Correlations between characteristics of nucleoli and presence of intranuclear vacuoles in malignant melanocytes and histopathological parameters

From: Nucleoli cytomorphology in cutaneous melanoma cells – a new prognostic approach to an old concept

Histopathological parameters Characteristics of nucleoli
Size Presence Number
Low High p value Low High p value Low High p value
Breslow thicknessa
 ≤ 1 mm 28 6 0.022 21 13 0.025 27 7 0.233
 1.01–2.00 mm 17 0 10 7 15 2
 2.01–4.00 mm 15 9 6 18 15 9
 > 4 mm 15 6 8 13 17 4
Clark levela
 II and III 55 8 0.003 35 28 0.032 48 15 0.806
 IV and V 20 13 10 23 26 7
Histologic typeb    0.316    0.012    0.511
 Superficial spreading melanoma (SSM) 53 11 36 28 50 14
 Nodular malignant melanoma (NMM) 20 9 9 20 21 8
 Acral-lentiginous melanoma (ALM) 2 1 0 3 3 0
Mitotic ratea
 0 40 4 0.006 28 16 0.004 37 7 0.152
 ≥ 1 35 17 17 35 37 15
Ulcerationc
 No 46 6 0.012 31 21 0.008 45 7 0.026
 Yes 29 15 14 30 29 15
TILs
 No 14 3   4 13   13 4 0.585
 Non-brisk 24 7 0.887 13 18 0.038 22 9
 Brisk 37 11 28 20 39 9
Microsatellitosisc
 No 74 17 0.008 44 47 0.363 73 18 0.010
 Yes 1 4 1 4 1 4
Lymphatic invasion
 No 55 16 1.000 36 35 0.248 58 13 0.098
 Yes 20 5 9 16 16 9
Tumor regressionc
 No 71 18 0.340 42 47 1.000 69 20 1.000
 Yes 4 3 3 4 5 2
  1. a p value of Wilcoxon two sample test
  2. b p value of chi2 test
  3. c p value of Fisher’s exact test;
  4. Statistically significant results (P < 0.05) are in bold text