Table 2 Correlations between characteristics of nucleoli and presence of intranuclear vacuoles in malignant melanocytes and histopathological parameters
From: Nucleoli cytomorphology in cutaneous melanoma cells – a new prognostic approach to an old concept
Histopathological parameters | Characteristics of nucleoli | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Size | Presence | Number | |||||||
Low | High | p value | Low | High | p value | Low | High | p value | |
Breslow thicknessa | |||||||||
≤ 1 mm | 28 | 6 | 0.022 | 21 | 13 | 0.025 | 27 | 7 | 0.233 |
1.01–2.00 mm | 17 | 0 | 10 | 7 | 15 | 2 | |||
2.01–4.00 mm | 15 | 9 | 6 | 18 | 15 | 9 | |||
> 4 mm | 15 | 6 | 8 | 13 | 17 | 4 | |||
Clark levela | |||||||||
II and III | 55 | 8 | 0.003 | 35 | 28 | 0.032 | 48 | 15 | 0.806 |
IV and V | 20 | 13 | 10 | 23 | 26 | 7 | |||
Histologic typeb | 0.316 | 0.012 | 0.511 | ||||||
Superficial spreading melanoma (SSM) | 53 | 11 | 36 | 28 | 50 | 14 | |||
Nodular malignant melanoma (NMM) | 20 | 9 | 9 | 20 | 21 | 8 | |||
Acral-lentiginous melanoma (ALM) | 2 | 1 | 0 | 3 | 3 | 0 | |||
Mitotic ratea | |||||||||
0 | 40 | 4 | 0.006 | 28 | 16 | 0.004 | 37 | 7 | 0.152 |
≥ 1 | 35 | 17 | 17 | 35 | 37 | 15 | |||
Ulcerationc | |||||||||
No | 46 | 6 | 0.012 | 31 | 21 | 0.008 | 45 | 7 | 0.026 |
Yes | 29 | 15 | 14 | 30 | 29 | 15 | |||
TILs | |||||||||
No | 14 | 3 | 4 | 13 | 13 | 4 | 0.585 | ||
Non-brisk | 24 | 7 | 0.887 | 13 | 18 | 0.038 | 22 | 9 | |
Brisk | 37 | 11 | 28 | 20 | 39 | 9 | |||
Microsatellitosisc | |||||||||
No | 74 | 17 | 0.008 | 44 | 47 | 0.363 | 73 | 18 | 0.010 |
Yes | 1 | 4 | 1 | 4 | 1 | 4 | |||
Lymphatic invasion | |||||||||
No | 55 | 16 | 1.000 | 36 | 35 | 0.248 | 58 | 13 | 0.098 |
Yes | 20 | 5 | 9 | 16 | 16 | 9 | |||
Tumor regressionc | |||||||||
No | 71 | 18 | 0.340 | 42 | 47 | 1.000 | 69 | 20 | 1.000 |
Yes | 4 | 3 | 3 | 4 | 5 | 2 | |||