Fig. 1From: Extramammary Paget disease of the vulva: immunohistochemical analysis of neoangiogenesis and epithelial-mesenchymal transition markers expressiona, b. Large cells (“Paget cells”) with pale cytoplasm and large nuclei with prominent nucleoli, arranged either singly or in clusters throughout the epithelium. b. Stromal invasion and lymphovascular space invasion (arrows) are evident (Hematoxylin & eosin; A: original magnification ×200; B: original magnification ×400)Back to article page