TY - JOUR AU - Bonaparte, Eleonora AU - Pesenti, Chiara AU - Fontana, Laura AU - Falcone, Rossella AU - Paganini, Leda AU - Marzorati, Anna AU - Ferrero, Stefano AU - Nosotti, Mario AU - Mendogni, Paolo AU - Bareggi, Claudia AU - Sirchia, Silvia Maria AU - Tabano, Silvia AU - Bosari, Silvano AU - Miozzo, Monica PY - 2018 DA - 2018/01/12 TI - Molecular profiling of lung cancer specimens and liquid biopsies using MALDI-TOF mass spectrometry JO - Diagnostic Pathology SP - 4 VL - 13 IS - 1 AB - Identification of predictive molecular alterations in lung adenocarcinoma is essential for accurate therapeutic decisions. Although several molecular approaches are available, a number of issues, including tumor heterogeneity, frequent material scarcity, and the large number of loci to be investigated, must be taken into account in selecting the most appropriate technique. MALDI-TOF mass spectrometry (MS), which allows multiplexed genotyping, has been adopted in routine diagnostics as a sensitive, reliable, fast, and cost-effective method. Our aim was to test the reliability of this approach in detecting targetable mutations in non-small cell lung cancer (NSCLC). In addition, we also analyzed low-quality samples, such as cytologic specimens, that often, are the unique source of starting material in lung cancer cases, to test the sensitivity of the system. SN - 1746-1596 UR - https://doi.org/10.1186/s13000-017-0683-7 DO - 10.1186/s13000-017-0683-7 ID - Bonaparte2018 ER -