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Table 3 Intra-and inter-observer kappa values for semi-quantitative estimates of tumour stroma ratio

From: Does heterogeneity matter in the estimation of tumour budding and tumour stroma ratio in colon cancer?

 

N

Kappa values (TSR: 4-groups)

Kappa values (TSR: High/Low)

Weighted kappa (TSR: 4 groups)

TSR-A1 & TSR-A2

129

0.68, p < 0.001

0.83, p < 0.001

0.77, p < 0.001

TSR-A1 & TSR-A2

43

0.65, p < 0.001

0.78, p < 0.001

0.75, p < 0.001

TSR-A1 & TSR-B

50

0.45, p < 0.001

0.75, p < 0.001

0.64, p < 0.001

TSR-A2 & TSR-B

50

0.47, p < 0.001

0.70, p < 0.001

0.67, p < 0.001

  1. Tumour stroma ratio was estimated semi-quantitatively by conventional microscopy. Intra-observer kappa values were calculated for all sections (n = 129) and the deepest invasive tumour section (n = 43), and inter-observer kappa values were calculated for 50 randomly selected sections. Kappa values were calculated for data expressed in four groups; TSR-4-groups (1: TSR > 75%, 2: 50% < TSR ≤ 75%, 3: 25% < TSR ≤ 50%, 4: TSR ≤ 25%) and data expressed in two groups; TSR high/low (high TSR = stroma ≤50% and low TSR: stroma > 50%)
  2. Abbreviations: TSR tumour stroma ratio; A1 First count by observer A; A2 second count by observer A; B count by observer B
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Diagnostic Pathology

ISSN: 1746-1596

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