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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Expression patterns of STAT3, ERK and estrogen-receptor α are associated with development and histologic severity of hepatic steatosis: a retrospective study

Fig. 2

Representative immunohistochemical features in hepatic steatosis (a-g) and the control group (h-i). (a) Nuclear and/or weak cytoplasmic and membranous expression of mammalian target of rapamycin (mTOR). (b) Nuclear staining of phosphorylated signal transducer and activator of transcription-3 (pSTAT3) in hepatocytes. (c) Double staining of pSTAT3 (nucleus) and α-smooth muscle actin (cytoplasm, red color) in hepatic stellate cells (arrows). (d) Double staining of extracellular signal-regulated kinase (pERK) (nucleus) and α-smooth muscle actin (cytoplasm, red color) in hepatic stellate cells (arrows). (e) Focal expression of estrogen-receptor α in hepatocyte nuclei. (f) Diffuse expression of estrogen-receptor α. (g) α-smooth muscle actin-positive cytoplasm in hepatic stellate cells. (h) Cytoplasmic and membranous staining of mTOR in non-neoplastic hepatocytes in a control sample. (i) Inconspicuous staining of α-smooth muscle actin (inactive hepatic stellate cells; center of figure) in a control sample, while strong positive staining in vessel walls as an internal positive control (left side of figure)

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