Skip to main content

Advertisement

Table 2 Comparison of protein expression features in hepatic steatosis patients and the control group

From: Expression patterns of STAT3, ERK and estrogen-receptor α are associated with development and histologic severity of hepatic steatosis: a retrospective study

  Total hepatic steatosis NAFLD AFLD Control *P value
  (N = 29) (n = 18) (n = 11) (N = 38)  
Protein expression in hepatocytes
 mTOR, positive 16 (55%) 14 (78%) 2 (18%) 1 (3%) < 0.001
 pSTAT3, positive 11 (38%) 3 (17%) 8 (73%) 4 (11%) 0.007
 pERK, positive 8 (28%) 4 (22%) 4 (36%) 1 (3%) 0.003
 Estrogen-receptor α, positive 29 (100%) 18 (100%) 11 (100%) 0 < 0.001
  Focal positive 7 (24%) 0 7 (64%) 0  
  Diffuse positive 22 (76%) 18 (100%) 4 (36%) 0  
Protein expression in hepatic stellate cells
 pSTAT3, positive 5 (17%) 0 5 (45%) 2 (5%) 0.055
 pERK, positive 29 (100%) 18 (100%) 11 (100%) 3 (8%) < 0.001
  1. NAFLD non-alcoholic fatty liver disease
  2. AFLD alcoholic fatty liver disease
  3. Control, non-neoplastic hepatosytes from 16 cases of biliary cyst and 22 cases of hepatolithiasis
  4. * P value between total hepatic steatosis group (N = 29) and the control group (N = 38)