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Table 2 Comparison of protein expression features in hepatic steatosis patients and the control group

From: Expression patterns of STAT3, ERK and estrogen-receptor α are associated with development and histologic severity of hepatic steatosis: a retrospective study

 

Total hepatic steatosis

NAFLD

AFLD

Control

*P value

 

(N = 29)

(n = 18)

(n = 11)

(N = 38)

 

Protein expression in hepatocytes

 mTOR, positive

16 (55%)

14 (78%)

2 (18%)

1 (3%)

< 0.001

 pSTAT3, positive

11 (38%)

3 (17%)

8 (73%)

4 (11%)

0.007

 pERK, positive

8 (28%)

4 (22%)

4 (36%)

1 (3%)

0.003

 Estrogen-receptor α, positive

29 (100%)

18 (100%)

11 (100%)

0

< 0.001

  Focal positive

7 (24%)

0

7 (64%)

0

 

  Diffuse positive

22 (76%)

18 (100%)

4 (36%)

0

 

Protein expression in hepatic stellate cells

 pSTAT3, positive

5 (17%)

0

5 (45%)

2 (5%)

0.055

 pERK, positive

29 (100%)

18 (100%)

11 (100%)

3 (8%)

< 0.001

  1. NAFLD non-alcoholic fatty liver disease
  2. AFLD alcoholic fatty liver disease
  3. Control, non-neoplastic hepatosytes from 16 cases of biliary cyst and 22 cases of hepatolithiasis
  4. * P value between total hepatic steatosis group (N = 29) and the control group (N = 38)