Fig. 1

TGR5 staining in normal renal cortex. a TGR5 is strongly expressed in the distal convoluted tubule, thin loop of Henle, and collecting duct (100X). b Absent or only minimal focal weak staining is observed in the proximal convoluted tubular cells (arrow, 400X). c In the glomeruli, TGR5 expression is not identified in the glomerular tufts while staining is present focally in the parietal epithelial cells (400X)