Fig. 2
From: GSK-3β inhibits autophagy and enhances radiosensitivity in non-small cell lung cancer
GSK-3β, p-GSK-3βSer9, and p-GSK-3βTyr216 expression in NSCLC tissues after X-ray irradiation. a, e, i, and M are the moderately differentiated adenocarcinoma tissues without X-ray irradiation, and b, f, j, and n are the tumor tissues that received 2-Gy X-ray irradiation. a and b are stained with HE (200×); e and f have immunohistochemical staining for GSK-3β; i and j have immunohistochemical staining for GSK-3βSer9; and m and n have immunohistochemical staining for GSK-3βTyr216. As shown in the figure, after 2-Gy X-ray irradiation of the adenocarcinoma samples, GSK-3β expression did not change significantly, but GSK-3βSer9 and GSK-3βTyr216 expression was significantly upregulated. c, g, k, and o are the poorly differentiated squamous cell carcinoma tissues without X-ray irradiation, and d, h, l, and p are the tumor tissues that received 2-Gy X-ray irradiation. c and d are stained with HE (200×); g and h have immunohistochemical staining for GSK-3β; k and l have immunohistochemical staining for GSK-3βSer9; and o and p have immunohistochemical staining for GSK-3βTyr216. As shown in the figure, after 2-Gy X-ray irradiation of the adenocarcinoma samples, GSK-3β and GSK-3βSer9 expression was downregulated, whereas GSK-3βTyr216 expression did not change significantly