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Fig. 3 | Diagnostic Pathology

Fig. 3

From: GSK-3β inhibits autophagy and enhances radiosensitivity in non-small cell lung cancer

Fig. 3

LC3, P62 and AMPK expression in NSCLC tissues after X-ray irradiation. After 2-Gy X-ray irradiation of the adenocarcinoma samples (moderately differentiated, a and b are stained with HE, 200×), LC3 expression was significantly upregulated (e is the control, and f indicates LC3 upregulation in the adenocarcinoma samples after X-ray irradiation); p62 expression was downregulated (i is the control, and j indicates p62 downregulation in the adenocarcinoma samples after X-ray irradiation); and AMPK expression was upregulated (m is the control, and n indicates AMPK upregulation in the adenocarcinoma samples after X-ray irradiation). After 2-Gy X-ray irradiation of the squamous cell carcinoma samples (poorly differentiated, c and d are stained with HE, 200×), LC3 expression was significantly upregulated (g is the control, and h indicates LC3 upregulation in the squamous cell carcinoma samples after X-ray irradiation); p62 expression was downregulated (k is the control, and l indicates p62 downregulation in the squamous cell carcinoma samples after X-ray irradiation); and AMPK expression was slightly upregulated (o is the control, and p indicates slight AMPK upregulation in the squamous cell carcinoma samples after X-ray irradiation)

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