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Fig. 4 | Diagnostic Pathology

Fig. 4

From: GSK-3β inhibits autophagy and enhances radiosensitivity in non-small cell lung cancer

Fig. 4

GSK-3β inhibited cellular autophagy. Western blotting showed that (a) after X-ray irradiation alone, GSK-3β and p62 levels decreased, whereas AMPK and LC3 levels did not change significantly in H460 cells. After transfection with GSK-3β with different activity levels, p62, AMPK, and LC3 levels decreased. After transfection with GSK-3β with different activity levels and X-ray irradiation, p62 levels increased, whereas AMPK and LC3 levels decreased. These changes were more significant for transfection with the active GSK-3β-S9A mutant than for transfection with the GSK-3β-WT or inactivated GSK-3β-K85R mutant (b, c, d). *P < 0.05

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