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Table 2 The association between PD-L1 expression, CD8+ T cell infiltration and clinicopathologic parameters in PNETs

From: Prognostic significance of PD-L1 expression and CD8+ T cell infiltration in pulmonary neuroendocrine tumors

Variable   PD-L1 expression CD8+ T cell density in stroma NA
N(%) Positive Negative p ≤264.6/mm2 >264.6/mm2 p
Total 159 (100.0) 72 (45.3) 87 (54.7)   80 (50.3) 79 (49.7)   
Age     0.241    0.578  
  ≤ 59.5 78 (49.1) 39 (54.2) 39 (44.8)   41 (51.3) 37 (46.8)   
 >59.5 81 (50.9) 33 (45.8) 48 (55.2)   39 (48.7) 42 (53.2)   
Gender     0.365    0.189  
 Male 109 (68.6) 52 (72.2) 57 (65.5)   51 (63.8) 58 (73.4)   
 Female 50 (31.4) 20 (27.8) 30 (34.5)   29 (36.3) 21 (26.6)   
Necrosis     < 0.001*    0.096  
 No 85 (53.5) 17 (23.6) 68 (78.2)   48 (60.0) 37 (46.8)   
 Yes 74 (46.5) 55 (76.4) 19 (21.8)   32 (40.0) 42 (53.2)   
Vascular invasion     0.072    0.004*  
 No 129 (81.1) 54 (75.0) 75 (86.2)   72 (90.0) 57 (72.2)   
 Yes 30 (18.9) 18 (25.0) 12 (13.8)   8 (10.0) 22 (27.8)   
Preoperative therapy     0.538    0.113  
 No 148 (93.1) 68 (94.4) 80 (92.0)   77 (96.3) 71 (89.8)   
 Yes 11 (6.9) 4 (5.6) 7 (8.0)   3(3.7) 8 (10.2)   
Tumor type     < 0.001*    0.005*  
 SCLC 94 (59.1) 48 (51.1) 46 (48.9)   50 (53.2) 44 (46.8)   
 LCNEC 28 (17.6) 21 (75.0) 7 (25.0)   7 (25.0) 21 (75.0)   
 TC 35 (22.0) 3 (8.6) 32 (91.4)   23 (65.7) 12 (34.3)   
 AC 2 (1.3) 0 (0.0) 2 (100.0)   0 (0.0) 2 (100.0)   
Pathological grading     < 0.001*    0.100  
 High 122 (76.7) 69 (95.8) 53 (60.9)   57 (71.2) 65 (82.3)   
 Low 37 (23.3) 3 (4.2) 34 (39.1)   23 (28.8) 14 (17.7)   
Lymph node metastasis     0.170    0.005* 13 (8.2)
 No 83 (56.8) 34 (50.7) 49 (62.8)   33 (45.2) 50 (68.5)   
 Yes 63 (43.2) 33 (49.3) 30 (37.2)   40 (54.8) 23 (31.5)   
Clinical Staging     0.314    0.007* 15 (9.4)
 I 70 (48.6) 29 (41.4) 41 (58.6)   27 (38.6) 43 (61.4)   
 II 27 (18.8) 10 (37.0) 17 (63.0)   14 (51.9) 13 (48.1)   
 III 47 (32.6) 25 (53.2) 22 (46.8)   32 68.1) 15 (31.9)   
  1. Abbreviation: NA not available
  2. *stands for the value of p < 0.05