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Table 3 The expression patterns of PD-L1 to clinicopathologic parameters in PNETs

From: Prognostic significance of PD-L1 expression and CD8+ T cell infiltration in pulmonary neuroendocrine tumors

  

PD-L1 expression

  

NA

N(%)

Tumorpos

Tumorneg

p

Stromapos

Stromaneg

p

Total

159 (100.0)

26 (16.4)

133 (83.6)

 

63 (39.6)

96 (60.4)

  

Age

   

0.593

  

0.497

 

  ≤ 59.5

78 (49.1)

14 (53.8)

64 (48.1)

 

33 (52.4)

45 (46.9)

  

 >59.5

81 (50.9)

12 (46.2)

69 (51.9)

 

30 (47.6)

51 (53.1)

  

Gender

   

0.142

  

0.527

 

 Male

109 (68.6)

21 (80.8)

88 (66.2)

 

45 (71.4)

64 (66.7)

  

 Female

50 (31.4)

5 (19.2)

45 (33.8)

 

18 (28.6)

32 (33.3)

  

Necrosis

   

0.094

  

< 0.001*

 

 No

85 (53.5)

10 (38.5)

75 (56.4)

 

11 (17.5)

74 (77.1)

  

 Yes

74 (46.5)

16 (61.5)

58 (43.6)

 

52 (82.5)

22 (22.9)

  

Vascular invasion

   

0.251

  

0.088

 

 No

129 (81.1)

19 (73.1)

110 (82.7)

 

47 (74.6)

82 (85.4)

  

 Yes

30 (18.9)

7 (26.9)

23 (17.3)

 

16 (25.4)

14 (14.6)

  

Preoperative therapy

   

0.865

  

0.819

 

 No

148 (93.1)

24 (92.3)

124 (93.2)

 

59 (93.7)

89 (92.7)

  

 Yes

11 (6.9)

2 (7.7)

9 (6.8)

 

4 (6.3)

7 (7.3)

  

Tumor type

   

0.066

  

< 0.001*

 

 SCLC

94 (59.1)

14 (14.9)

80 (85.1)

 

47 (50)

47 (50)

  

 LCNEC

28 (17.6)

9 (32.1)

19 (67.9)

 

16 (57.1)

12 (42.9)

  

 TC

35 (22.0)

3 (8.6)

32 (91.4)

 

0 (0.0)

35 (100.0)

  

 AC

2 (1.3)

0 (0.0)

2 (100.0)

 

0 (0.0)

2 (100.0)

  

Pathological grading

   

0.122

  

< 0.001*

 

 High

122 (76.7)

23 (88.5)

99 (74.4)

 

63 (100.0)

59 (61.5)

  

 Low

37 (23.3)

3 (11.5)

34 (25.6)

 

0 (0.0)

37 (38.5)

  

Lymph node metastasis

   

0.377

  

0.113

13 (8.2)

 No

83 (52.2)

15 (65.2)

68 (55.3)

 

30 (49.2)

53 (62.4)

  

 Yes

63 (47.8)

8 (34.8)

55 (44.7)

 

31 (50.8)

32 (37.6)

  

Clinical Staging

   

0.309

  

0.077

15 (9.4)

 I

70 (48.6)

14 (63.6)

56 (45.9)

 

25 (43.1)

45 (52.3)

  

 II

27 (18.8)

3 (13.6)

24 (19.7)

 

8 (13.8)

19 (22.1)

  

 III

47 (32.6)

5 (22.7)

42 (34.4)

 

25 (43.1)

22 (25.6)

  

CD8 density/mm2 in stroma

   

0.002*

  

0.005*

 

  ≤ 264.6/mm2

80 (50.3)

6 (23.1)

74 (55.6)

 

23 (36.5)

57 (59.4)

  

 >264.6/mm2

79 (49.7)

20 (76.9)

59 (44.4)

 

40 (63.5)

39 (40.6)

  
  1. Abbreviation: NA not available
  2. *stands for the value of p < 0.05