PD-L1 expression | NA | |||||||
---|---|---|---|---|---|---|---|---|
N(%) | Tumorpos | Tumorneg | p | Stromapos | Stromaneg | p | ||
Total | 159 (100.0) | 26 (16.4) | 133 (83.6) | 63 (39.6) | 96 (60.4) | |||
Age | 0.593 | 0.497 | ||||||
≤ 59.5 | 78 (49.1) | 14 (53.8) | 64 (48.1) | 33 (52.4) | 45 (46.9) | |||
>59.5 | 81 (50.9) | 12 (46.2) | 69 (51.9) | 30 (47.6) | 51 (53.1) | |||
Gender | 0.142 | 0.527 | ||||||
Male | 109 (68.6) | 21 (80.8) | 88 (66.2) | 45 (71.4) | 64 (66.7) | |||
Female | 50 (31.4) | 5 (19.2) | 45 (33.8) | 18 (28.6) | 32 (33.3) | |||
Necrosis | 0.094 | < 0.001* | ||||||
No | 85 (53.5) | 10 (38.5) | 75 (56.4) | 11 (17.5) | 74 (77.1) | |||
Yes | 74 (46.5) | 16 (61.5) | 58 (43.6) | 52 (82.5) | 22 (22.9) | |||
Vascular invasion | 0.251 | 0.088 | ||||||
No | 129 (81.1) | 19 (73.1) | 110 (82.7) | 47 (74.6) | 82 (85.4) | |||
Yes | 30 (18.9) | 7 (26.9) | 23 (17.3) | 16 (25.4) | 14 (14.6) | |||
Preoperative therapy | 0.865 | 0.819 | ||||||
No | 148 (93.1) | 24 (92.3) | 124 (93.2) | 59 (93.7) | 89 (92.7) | |||
Yes | 11 (6.9) | 2 (7.7) | 9 (6.8) | 4 (6.3) | 7 (7.3) | |||
Tumor type | 0.066 | < 0.001* | ||||||
SCLC | 94 (59.1) | 14 (14.9) | 80 (85.1) | 47 (50) | 47 (50) | |||
LCNEC | 28 (17.6) | 9 (32.1) | 19 (67.9) | 16 (57.1) | 12 (42.9) | |||
TC | 35 (22.0) | 3 (8.6) | 32 (91.4) | 0 (0.0) | 35 (100.0) | |||
AC | 2 (1.3) | 0 (0.0) | 2 (100.0) | 0 (0.0) | 2 (100.0) | |||
Pathological grading | 0.122 | < 0.001* | ||||||
High | 122 (76.7) | 23 (88.5) | 99 (74.4) | 63 (100.0) | 59 (61.5) | |||
Low | 37 (23.3) | 3 (11.5) | 34 (25.6) | 0 (0.0) | 37 (38.5) | |||
Lymph node metastasis | 0.377 | 0.113 | 13 (8.2) | |||||
No | 83 (52.2) | 15 (65.2) | 68 (55.3) | 30 (49.2) | 53 (62.4) | |||
Yes | 63 (47.8) | 8 (34.8) | 55 (44.7) | 31 (50.8) | 32 (37.6) | |||
Clinical Staging | 0.309 | 0.077 | 15 (9.4) | |||||
I | 70 (48.6) | 14 (63.6) | 56 (45.9) | 25 (43.1) | 45 (52.3) | |||
II | 27 (18.8) | 3 (13.6) | 24 (19.7) | 8 (13.8) | 19 (22.1) | |||
III | 47 (32.6) | 5 (22.7) | 42 (34.4) | 25 (43.1) | 22 (25.6) | |||
CD8 density/mm2 in stroma | 0.002* | 0.005* | ||||||
≤ 264.6/mm2 | 80 (50.3) | 6 (23.1) | 74 (55.6) | 23 (36.5) | 57 (59.4) | |||
>264.6/mm2 | 79 (49.7) | 20 (76.9) | 59 (44.4) | 40 (63.5) | 39 (40.6) |