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Table 3 The expression patterns of PD-L1 to clinicopathologic parameters in PNETs

From: Prognostic significance of PD-L1 expression and CD8+ T cell infiltration in pulmonary neuroendocrine tumors

   PD-L1 expression    NA
N(%) Tumorpos Tumorneg p Stromapos Stromaneg p
Total 159 (100.0) 26 (16.4) 133 (83.6)   63 (39.6) 96 (60.4)   
Age     0.593    0.497  
  ≤ 59.5 78 (49.1) 14 (53.8) 64 (48.1)   33 (52.4) 45 (46.9)   
 >59.5 81 (50.9) 12 (46.2) 69 (51.9)   30 (47.6) 51 (53.1)   
Gender     0.142    0.527  
 Male 109 (68.6) 21 (80.8) 88 (66.2)   45 (71.4) 64 (66.7)   
 Female 50 (31.4) 5 (19.2) 45 (33.8)   18 (28.6) 32 (33.3)   
Necrosis     0.094    < 0.001*  
 No 85 (53.5) 10 (38.5) 75 (56.4)   11 (17.5) 74 (77.1)   
 Yes 74 (46.5) 16 (61.5) 58 (43.6)   52 (82.5) 22 (22.9)   
Vascular invasion     0.251    0.088  
 No 129 (81.1) 19 (73.1) 110 (82.7)   47 (74.6) 82 (85.4)   
 Yes 30 (18.9) 7 (26.9) 23 (17.3)   16 (25.4) 14 (14.6)   
Preoperative therapy     0.865    0.819  
 No 148 (93.1) 24 (92.3) 124 (93.2)   59 (93.7) 89 (92.7)   
 Yes 11 (6.9) 2 (7.7) 9 (6.8)   4 (6.3) 7 (7.3)   
Tumor type     0.066    < 0.001*  
 SCLC 94 (59.1) 14 (14.9) 80 (85.1)   47 (50) 47 (50)   
 LCNEC 28 (17.6) 9 (32.1) 19 (67.9)   16 (57.1) 12 (42.9)   
 TC 35 (22.0) 3 (8.6) 32 (91.4)   0 (0.0) 35 (100.0)   
 AC 2 (1.3) 0 (0.0) 2 (100.0)   0 (0.0) 2 (100.0)   
Pathological grading     0.122    < 0.001*  
 High 122 (76.7) 23 (88.5) 99 (74.4)   63 (100.0) 59 (61.5)   
 Low 37 (23.3) 3 (11.5) 34 (25.6)   0 (0.0) 37 (38.5)   
Lymph node metastasis     0.377    0.113 13 (8.2)
 No 83 (52.2) 15 (65.2) 68 (55.3)   30 (49.2) 53 (62.4)   
 Yes 63 (47.8) 8 (34.8) 55 (44.7)   31 (50.8) 32 (37.6)   
Clinical Staging     0.309    0.077 15 (9.4)
 I 70 (48.6) 14 (63.6) 56 (45.9)   25 (43.1) 45 (52.3)   
 II 27 (18.8) 3 (13.6) 24 (19.7)   8 (13.8) 19 (22.1)   
 III 47 (32.6) 5 (22.7) 42 (34.4)   25 (43.1) 22 (25.6)   
CD8 density/mm2 in stroma     0.002*    0.005*  
  ≤ 264.6/mm2 80 (50.3) 6 (23.1) 74 (55.6)   23 (36.5) 57 (59.4)   
 >264.6/mm2 79 (49.7) 20 (76.9) 59 (44.4)   40 (63.5) 39 (40.6)   
  1. Abbreviation: NA not available
  2. *stands for the value of p < 0.05