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Table 1 Patient and tumor characteristics

From: No evidence for human papillomavirus having a causal role in salivary gland tumors

Histological subtypea

Tumors (N)

Age (mean)

TNM-stageb

Available regional metastasis

HPV DNA+ primary tumorsc

HPV DNA+ regional metastasisc

T

N

M

T1

T2

T3

T4

N0

N1

N2

M0

M1

Acinic cell carcinoma

22

54

9

10

2

1

22

0

0

22

0

–

0

–

Adenocarcinoma, UNS

19

66

3

8

2

6

13

2

4

17

2

4/6

0

0

Adenoid cystic carcinoma

13

55

5

6

1

1

13

0

0

1

2

–

0

–

Basal cell adenocarcinoma

3

75

2

0

1

0

3

0

0

3

0

–

0

–

Epithelial-myoepithelial carcinoma

4

75

1

2

1

0

4

0

0

4

0

–

0

–

Mucoepidermoid carcinoma

22

47

11

9

0

2

21

1

0

21

1

0/1

0

0

Myoepithelial carcinoma

2

53

0

2

0

0

1

0

1

1

1

1/1

0

0

Oncocytic carcinoma

1

65

0

1

0

0

1

0

0

1

0

–

0

–

Poorly differentiated carcinoma

3

85

0

1

1

1

1

1

1

3

0

1/2

0

0

Salivary duct carcinoma

10

57

2

3

1

4

4

2

4

9

1

2/6

0

0

Secretory carcinoma

1

85

1

0

0

0

1

0

0

1

0

–

0

–

Squamous cell carcinoma

7

56

2

2

3

0

4

1

2

7

0

2/3

1d, e

1d

Total

107

59

         

10

1

1

  1. aHistological subtype according to WHO 2017
  2. bTNM-stage according to AJCC 7th Ed
  3. cHuman papillomavirus DNA positivity (HPV DNA+) as assessed by presence of HPV DNA by Luminex Multiplex PCR
  4. dPrimary tumor and regional metastasis obtained from the same patient
  5. eFischer’s exact test for HPV positivity in squamous cell carcinoma vs. all other sub-types: p = 0.06
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Diagnostic Pathology

ISSN: 1746-1596

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