Skip to main content

Table 3 Intra-block concordance (OPA) in PD-L1 classification at various applied cut-offs

From: Consistency of tumor and immune cell programmed cell death ligand-1 expression within and between tumor blocks using the VENTANA SP263 assay

Applied cut-off

Concordance (OPA), %

NSCLC

HNSCC

UC

TC PD-L1 staining

  ≥ 50%

100

100

100

  ≥ 25%

100

100

100

  ≥ 10%

100

100

100

  ≥ 1%

100

100

100

IC PD-L1 staining

  ≥ 25%

100

100

100

  ≥ 10%

70

90

100

  ≥ 5%

90

100

80

  ≥ 1%

100

100

80

  1. Fifteen NSCLC, HNSCC or UC cases; 30 blocks in total (10 blocks per indication)
  2. HNSCC head and neck squamous cell carcinoma, IC tumor-infiltrating immune cell, NSCLC non-small cell lung cancer, OPA overall percentage agreement, PD-L1 programmed cell death ligand-1, TC tumor cell, UC urothelial carcinoma