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Table 5 Intra-case concordance (OPA) in PD-L1 classification at various applied cut-offs

From: Consistency of tumor and immune cell programmed cell death ligand-1 expression within and between tumor blocks using the VENTANA SP263 assay

Applied cut-off

Concordance (OPA), %

NSCLC

HNSCC

UC

TC PD-L1 staining

 ≥50%

80

100

100

 ≥25%

100

100

100

 ≥10%

100

100

100

 ≥1%

100

100

100

IC PD-L1 staining

 ≥25%

100

100

100

 ≥10%

60

80

100

 ≥5%

80

100

80

 ≥1%

100

80

60

  1. Fifteen NSCLC, HNSCC or UC cases (five cases per indication)
  2. HNSCC head and neck squamous cell carcinoma, IC tumor-infiltrating immune cell, NSCLC non-small cell lung cancer, OPA overall percentage agreement, PD-L1 programmed cell death ligand-1, TC tumor cell, UC urothelial carcinoma
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Diagnostic Pathology

ISSN: 1746-1596

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